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Translocation of a knotted polypeptide through a pore
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10.1063/1.2968554
/content/aip/journal/jcp/129/12/10.1063/1.2968554
http://aip.metastore.ingenta.com/content/aip/journal/jcp/129/12/10.1063/1.2968554
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Our model consists of an unstructured knotted chain segment enclosed by two -hairpins. A force is applied at one end of the chain causing its translocation through a cylindrical pore of radius and length .

Image of FIG. 2.
FIG. 2.

The time dependence of the position of the leading chain end measured along the pore axis for several translocation trajectories. The pore entrance corresponds to . The values of the force used are , 72, 90, and for the trajectories with no knot, and with the , , and knots, respectively.

Image of FIG. 3.
FIG. 3.

An example of a translocation trajectory for a chain containing a knot: The time dependence of the position of the leading chain end and snapshots of the protein structure at different times.

Image of FIG. 4.
FIG. 4.

The force dependence of the translocation rate (defined as the inverse mean translocation time). The straight lines are linear fits of the low-force data.

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/content/aip/journal/jcp/129/12/10.1063/1.2968554
2008-09-30
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Translocation of a knotted polypeptide through a pore
http://aip.metastore.ingenta.com/content/aip/journal/jcp/129/12/10.1063/1.2968554
10.1063/1.2968554
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