1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
f
Force-clamp spectroscopy of reversible bond breakage
Rent:
Rent this article for
Access full text Article
/content/aip/journal/jcp/130/4/10.1063/1.3071199
1.
1.E. Evans, Annu. Rev. Biophys. Biomol. Struct. 30, 105 (2001).
http://dx.doi.org/10.1146/annurev.biophys.30.1.105
2.
2.X. Zhuang and M. Rief, Curr. Opin. Struct. Biol. 13, 88 (2003).
http://dx.doi.org/10.1016/S0959-440X(03)00011-3
3.
3.F. Ritort, J. Phys.: Condens. Matter 18, R531 (2006).
http://dx.doi.org/10.1088/0953-8984/18/32/R01
4.
4.J. Fernandez and H. Li, Science 303, 1674 (2004).
http://dx.doi.org/10.1126/science.1092497
5.
5.M. Schlierf, H. Li, and J. Fernandez, Proc. Natl. Acad. Sci. U.S.A. 101, 7299 (2004).
http://dx.doi.org/10.1073/pnas.0400033101
6.
6.K. Schulten, Z. Schulten, and A. Szabo, J. Chem. Phys. 74, 4426 (1981).
http://dx.doi.org/10.1063/1.441684
7.
7.G. Bell, Science 200, 618 (1978).
http://dx.doi.org/10.1126/science.347575
8.
8.G. Hummer and A. Szabo, Biophys. J. 85, 5 (2003).
http://dx.doi.org/10.1016/S0006-3495(03)74449-X
9.
9.O. Dudko, G. Hummer, and A. Szabo, Phys. Rev. Lett. 96, 108101 (2006).
http://dx.doi.org/10.1103/PhysRevLett.96.108101
10.
10.U. Seifert, Europhys. Lett. 58, 792 (2002).
http://dx.doi.org/10.1209/epl/i2002-00101-8
11.
11.F. Li and D. Leckband, J. Chem. Phys. 125, 194702 (2006).
http://dx.doi.org/10.1063/1.2372493
12.
12.G. Diezemann and A. Janshoff, J. Chem. Phys. 129, 084904 (2008).
http://dx.doi.org/10.1063/1.2968543
13.
13.M. Manosas, D. Collin, and F. Ritort, Phys. Rev. Lett. 96, 218301 (2006).
http://dx.doi.org/10.1103/PhysRevLett.96.218301
14.
14.J. Liphardt, B. Onoa, S. Smith, I. Tinoco, and C. Bustamante, Science 292, 733 (2001).
http://dx.doi.org/10.1126/science.1058498
15.
15.C. Chia-Lin Chyan, Fan-Chi Lin, Haibo Peng, Jian-Min Yuan, Chung-Hung Chang, Sheng-Hsien Lin, and Guoliang Yang, Biophys. J. 87, 3995 (2004).
http://dx.doi.org/10.1529/biophysj.104.042754
16.
16.M. Janke, Y. Rudzevich, O. Molokanova, T. Metzroth, I. Mey, G. Diezemann, P. E. Marszalek, J. Gauss, V. Böhmer, and A. Janshoff, “Mechanically interlocked calix[4]arene dimers display reversible bond breakage under force,” Nat. Nanotechnol. (in press).
17.
17.E. Barkai, Y. Jung, and R. Silbey, Annu. Rev. Phys. Chem. 55, 457 (2004).
http://dx.doi.org/10.1146/annurev.physchem.55.111803.143246
18.
18.C. Hyeon and D. Thirumalai, J. Phys.: Condens. Matter 19, 113101 (2007).
http://dx.doi.org/10.1088/0953-8984/19/11/113101
19.
19.H. Frauenfelder, S. G. Sligar, and P. G. Wolynes, Science 254, 1598 (1991).
http://dx.doi.org/10.1126/science.1749933
20.
20.V. Barsegov, G. Morrison, and D. Thirumalai, Phys. Rev. Lett. 100, 248102 (2008).
http://dx.doi.org/10.1103/PhysRevLett.100.248102
21.
21.F. Brown, Phys. Rev. Lett. 90, 028302 (2003).
http://dx.doi.org/10.1103/PhysRevLett.90.028302
22.
22.F. Brown, Acc. Chem. Res. 39, 363 (2006).
http://dx.doi.org/10.1021/ar050028l
23.
23.N. van Kampen, Stochastic Processes in Physics and Chemistry (North-Holland, Amsterdam, 1981).
24.
24.M. Rief, J. Fernandez, and H. Gaub, Phys. Rev. Lett. 81, 4764 (1998).
http://dx.doi.org/10.1103/PhysRevLett.81.4764
25.
25.R. Zwanzig, Acc. Chem. Res. 23, 148 (1990).
http://dx.doi.org/10.1021/ar00173a005
26.
26.J. Wang and P. Wolynes, Phys. Rev. Lett. 74, 4317 (1995).
http://dx.doi.org/10.1103/PhysRevLett.74.4317
http://aip.metastore.ingenta.com/content/aip/journal/jcp/130/4/10.1063/1.3071199
Loading
/content/aip/journal/jcp/130/4/10.1063/1.3071199
Loading

Data & Media loading...

Loading

Article metrics loading...

/content/aip/journal/jcp/130/4/10.1063/1.3071199
2009-01-23
2014-09-18

Abstract

We consider reversible breaking of adhesionbonds or folding of proteins under the influence of a constant external force. We discuss the statistical properties of the unbinding/rebinding events and analyze their mean number and their variance in the framework of simple kinetic models. In the calculations, we explicitly exploit the analogy to single molecule fluorescence and particularly between unbinding/rebinding and photon emission events. Whereas for two-state behavior Poisson or sub-Poisson statistics of the events is found, we show that for more general kinetic schemes also super-Poisson statistics can occur. Temporal fluctuations of the transition rates, a hallmark for the presence of dynamic disorder, should become experimentally accessible via the determination of the second moment of the event-number distribution.

Loading

Full text loading...

/deliver/fulltext/aip/journal/jcp/130/4/1.3071199.html;jsessionid=cqsfoff8h8o23.x-aip-live-06?itemId=/content/aip/journal/jcp/130/4/10.1063/1.3071199&mimeType=html&fmt=ahah&containerItemId=content/aip/journal/jcp
true
true
This is a required field
Please enter a valid email address
This feature is disabled while Scitation upgrades its access control system.
This feature is disabled while Scitation upgrades its access control system.
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Force-clamp spectroscopy of reversible bond breakage
http://aip.metastore.ingenta.com/content/aip/journal/jcp/130/4/10.1063/1.3071199
10.1063/1.3071199
SEARCH_EXPAND_ITEM