Skip to main content

News about Scitation

In December 2016 Scitation will launch with a new design, enhanced navigation and a much improved user experience.

To ensure a smooth transition, from today, we are temporarily stopping new account registration and single article purchases. If you already have an account you can continue to use the site as normal.

For help or more information please visit our FAQs.

banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
/content/aip/journal/jcp/131/24/10.1063/1.3279305
1.
1.J. Howard, Mechanics of Motor Proteins and the Cytoskeleton (Sinauer Associates, Sunderland, MA, 2001).
2.
2.D. L. Coy, M. Wagenbach, and J. Howard, J. Biol. Chem. 274, 3667 (1999).
http://dx.doi.org/10.1074/jbc.274.6.3667
3.
3.K. Visscher, M. J. Schnitzer, and S. M. Block, Nature (London) 400, 184 (1999).
http://dx.doi.org/10.1038/22146
4.
4.S. P. Gross, M. Vershinin, and G. T. Shubeita, Curr. Biol. 17, R478 (2007).
http://dx.doi.org/10.1016/j.cub.2007.04.025
5.
5.G. Koster, M. van Duijn, B. Hofs, and M. Dogterom, Proc. Natl. Acad. Sci. U.S.A. 100, 15583 (2003).
http://dx.doi.org/10.1073/pnas.2531786100
6.
6.C. Leduc, O. Campas, K. B. Zeldovich, A. Roux, P. Jolimaitre, L. Bourel-Bonnet, B. Goud, J. -F. Joanny, P. Bassereau, and J. Prost, Proc. Natl. Acad. Sci. U.S.A. 101, 17096 (2004).
http://dx.doi.org/10.1073/pnas.0406598101
7.
7.S. Klumpp and R. Lipowsky, Proc. Natl. Acad. Sci. U.S.A. 102, 17284 (2005).
http://dx.doi.org/10.1073/pnas.0507363102
8.
8.L. S. Goldstein and Z. Yang, Annu. Rev. Neurosci. 23, 39 (2000).
http://dx.doi.org/10.1146/annurev.neuro.23.1.39
9.
9.D. B. Hill, M. J. Plaza, K. Bonin, and G. Holzwarth, Eur. Biophys. J. 33, 623 (2004).
http://dx.doi.org/10.1007/s00249-004-0403-6
10.
10.S. P. Gross, Phys. Biol. 1, R1 (2004).
http://dx.doi.org/10.1088/1478-3967/1/2/R01
11.
11.M. J. I. Müller, S. Klumpp, and R. Lipowsky, Proc. Natl. Acad. Sci. U.S.A. 105, 4609 (2008).
http://dx.doi.org/10.1073/pnas.0706825105
12.
12.S. M. Block, L. S. Goldstein, and B. J. Schnapp, Nature (London) 348, 348 (1990).
http://dx.doi.org/10.1038/348348a0
13.
13.K. J. Böhm, R. Stracke, P. Mühlig, and E. Unger, Nanotechnology 12, 238 (2001).
http://dx.doi.org/10.1088/0957-4484/12/3/307
14.
14.J. Beeg, S. Klumpp, R. Dimova, R. Serral Gracià, E. Unger, and R. Lipowsky, Biophys. J. 94, 532 (2008).
http://dx.doi.org/10.1529/biophysj.106.097881
15.
15.M. Vershinin, B. C. Carter, D. S. Razafsky, S. J. King, and S. P. Gross, Proc. Natl. Acad. Sci. U.S.A. 104, 87 (2007).
http://dx.doi.org/10.1073/pnas.0607919104
16.
16.A. R. Rogers, J. W. Driver, P. E. Constantinou, D. K. Jamison, and M. R. Diehl, Phys. Chem. Chem. Phys. 11, 4882 (2009).
http://dx.doi.org/10.1039/b900964g
17.
17.A. Kunwar, M. Vershinin, J. Xu, and S. P. Gross, Curr. Biol. 18, 1173 (2008).
http://dx.doi.org/10.1016/j.cub.2008.07.027
18.
18.D. A. Lauffenburger and J. J. Linderman, Receptors (Oxford University Press, Oxford, 1993).
19.
19.T. Erdmann and U. S. Schwarz, Phys. Rev. Lett. 92, 108102 (2004).
http://dx.doi.org/10.1103/PhysRevLett.92.108102
20.
20.T. Erdmann and U. S. Schwarz, J. Chem. Phys. 121, 8997 (2004).
21.
21.T. A. Springer, Cell 76, 301 (1994).
http://dx.doi.org/10.1016/0092-8674(94)90337-9
22.
22.D. A. Hammer and S. M. Apte, Biophys. J. 63, 35 (1992).
http://dx.doi.org/10.1016/S0006-3495(92)81577-1
23.
23.C. B. Korn and U. S. Schwarz, Phys. Rev. E 77, 041904 (2008).
http://dx.doi.org/10.1103/PhysRevE.77.041904
24.
24.Molecular Motors, edited by M. Schliwa (Wiley-VCH, New York, 2003).
25.
25.L. Limberis, J. J. Magda, and R. J. Stewart, Nano Lett. 1, 277 (2001).
http://dx.doi.org/10.1021/nl0155375
26.
26.C. B. Korn and U. S. Schwarz, J. Chem. Phys. 126, 095103 (2007).
http://dx.doi.org/10.1063/1.2464080
27.
27.D. L. Ermak and J. A. McCammon, J. Chem. Phys. 69, 1352 (1978).
http://dx.doi.org/10.1063/1.436761
28.
28.J. F. Brady and G. Bossis, Annu. Rev. Fluid Mech. 20, 111 (1988).
http://dx.doi.org/10.1146/annurev.fl.20.010188.000551
29.
29.B. Cichocki and R. B. Jones, Physica A 258, 273 (1998).
http://dx.doi.org/10.1016/S0378-4371(98)00267-2
30.
30.W. Horthshemke and R. Lefever, Noise-Induced Transitions (Springer-Verlag, Berlin, 1984).
31.
31.G. S. Perkins and R. B. Jones, Physica A 189, 447 (1992).
http://dx.doi.org/10.1016/0378-4371(92)90056-V
32.
32.K. Svoboda, C. F. Schmidt, B. J. Schnapp, and S. M. Block, Nature (London) 365, 721 (1993).
http://dx.doi.org/10.1038/365721a0
33.
33.F. Gibbons, J. -F. Chauwin, M. Despósito, and J. V. José, Biophys. J. 80, 2515 (2001).
http://dx.doi.org/10.1016/S0006-3495(01)76223-6
34.
34.T. Duke and S. Leibler, Biophys. J. 71, 1235 (1996).
http://dx.doi.org/10.1016/S0006-3495(96)79323-2
35.
35.M. J. Schnitzer, K. Visscher, and S. M. Block, Nat. Cell Biol. 2, 718 (2000).
http://dx.doi.org/10.1038/35036345
36.
36.A. Rohrbach, E. -L. Florin, and E. H. K. Stelzer, Proc. SPIE 4431, 75 (2001).
http://dx.doi.org/10.1117/12.447404
37.
37.J. Kerssemakers, J. Howard, H. Hess, and S. Diez, Proc. Natl. Acad. Sci. U.S.A. 103, 15812 (2006).
http://dx.doi.org/10.1073/pnas.0510400103
38.
38.G. I. Bell, Science 200, 618 (1978).
http://dx.doi.org/10.1126/science.347575
39.
39.K. Svoboda and S. M. Block, Cell 77, 773 (1994).
http://dx.doi.org/10.1016/0092-8674(94)90060-4
40.
40.N. J. Carter and R. A. Cross, Nature (London) 435, 308 (2005).
http://dx.doi.org/10.1038/nature03528
41.
41.S. M. Block, C. L. Asbury, J. W. Shaevitz, and M. J. Lang, Proc. Natl. Acad. Sci. U.S.A. 100, 2351 (2003).
http://dx.doi.org/10.1073/pnas.0436709100
42.
42.R. Lipowsky, S. Klumpp, and T. M. Nieuwenhuizen, Phys. Rev. Lett. 87, 108101 (2001).
http://dx.doi.org/10.1103/PhysRevLett.87.108101
43.
43.S. Chen and T. A. Springer, Proc. Natl. Acad. Sci. U.S.A. 98, 950 (2001).
http://dx.doi.org/10.1073/pnas.98.3.950
44.
44.C. Korn, “Stochastic dynamics of cell adhesion in hydrodynamic flow,” Ph.D. thesis, Potsdam University, 2007.
45.
45.C. L. Asbury, A. N. Fehr, and S. M. Block, Science 302, 2130 (2003).
http://dx.doi.org/10.1126/science.1092985
46.
46.W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery, Numerical Recipes in C, 2nd ed. (Cambridge University Press, Cambridge, 1994).
47.
47.C. W. Gardiner, Handbook of Stochastic Methods (Springer-Verlag, Berlin, 1985).
48.
48.A. J. Hunt, F. Gittes, and J. Howard, Biophys. J. 67, 766 (1994).
http://dx.doi.org/10.1016/S0006-3495(94)80537-5
49.
49.V. Levi, A. S. Serpinskaya, E. Gratton, and V. Gelfand, Biophys. J. 90, 318 (2006).
http://dx.doi.org/10.1529/biophysj.105.067843
50.
50.M. Matsumoto and T. Nishimura, ACM Trans. Model. Comput. Simul. 8, 3 (1998).
http://dx.doi.org/10.1145/272991.272995
http://aip.metastore.ingenta.com/content/aip/journal/jcp/131/24/10.1063/1.3279305
Loading
/content/aip/journal/jcp/131/24/10.1063/1.3279305
Loading

Data & Media loading...

Loading

Article metrics loading...

/content/aip/journal/jcp/131/24/10.1063/1.3279305
2009-12-31
2016-12-10

Abstract

We use stochastic computer simulations to study the transport of a spherical cargo particle along a microtubule-like track on a planar substrate by several kinesin-like processive motors. Our newly developed adhesive motor dynamics algorithm combines the numerical integration of a Langevin equation for the motion of a sphere with kinetic rules for the molecular motors. The Langevin part includes diffusive motion, the action of the pulling motors, and hydrodynamic interactions between sphere and wall. The kinetic rules for the motors include binding to and unbinding from the filament as well as active motor steps. We find that the simulated mean transport length increases exponentially with the number of bound motors, in good agreement with earlier results. The number of motors in binding range to the motor track fluctuates in time with a Poissonian distribution, both for springs and cables being used as models for the linker mechanics. Cooperativity in the sense of equal load sharing only occurs for high values for viscosity and attachment time.

Loading

Full text loading...

/deliver/fulltext/aip/journal/jcp/131/24/1.3279305.html;jsessionid=KppiqiJU16pV7UizBNWXwKB-.x-aip-live-06?itemId=/content/aip/journal/jcp/131/24/10.1063/1.3279305&mimeType=html&fmt=ahah&containerItemId=content/aip/journal/jcp
true
true

Access Key

  • FFree Content
  • OAOpen Access Content
  • SSubscribed Content
  • TFree Trial Content
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
/content/realmedia?fmt=ahah&adPositionList=
&advertTargetUrl=//oascentral.aip.org/RealMedia/ads/&sitePageValue=jcp.aip.org/131/24/10.1063/1.3279305&pageURL=http://scitation.aip.org/content/aip/journal/jcp/131/24/10.1063/1.3279305'
Right1,Right2,Right3,