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Formation of globules and aggregates of DNA chains in DNA/polyethylene glycol/monovalent salt aqueous solutions
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View: Figures


Image of FIG. 1.
FIG. 1.

Typical snapshots of the probed DNA in the solutions containing unprobed DNA at with various salt concentrations. (a) A random coiled DNA at , (b) a globular DNA at , and (c) an elongated DNA at . (d)–(f) show illustrations of (a)–(c).

Image of FIG. 2.
FIG. 2.

The average dimension of DNA plotted against the salt concentration for the solutions containing (a) PEG6000 and (b) PEG20000. Filled circles, filled triangles, and open circles represent random coiled, globular, and elongated DNA, respectively.

Image of FIG. 3.
FIG. 3.

Distribution of the DNA dimension at various DNA concentrations (indicated in the figure) for the solutions containing (a) PEG6000 and (b) PEG20000.

Image of FIG. 4.
FIG. 4.

Illustration of microscopic structures for globular DNAs and DNA aggregates considered in the free energy model.

Image of FIG. 5.
FIG. 5.

The total free energy per chain in the presence of PEG6000 as a function of the distance between DNA segments for (a) globular DNA (isolated) and (b) elongated DNA (in the aggregate) for various Debye lengths . Horizontal broken line shows the free energy of random coiled DNA for comparison.

Image of FIG. 6.
FIG. 6.

The steady state solutions of and plotted against . Bold, dotted, broken, and thin lines indicate the solutions for , 2/3, 1/3, and 0, respectively.

Image of FIG. 7.
FIG. 7.

The number fraction of DNA globules and aggregates plotted against the DNA concentration . Filled and unfilled symbols are experimental values of and for PEG6000 (circles) and PEG 20000 (triangles), respectively. Solid and broken curves are the steady state solution for and obtained by the kinetic model at for PEG6000 (thin curves) and PEG20000 (bold curves).

Image of FIG. 8.
FIG. 8.

Illustration of the model for the depletion interaction. Gray circles represent cylinders (DNAs) and the dark gray represents the depletion region.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Formation of globules and aggregates of DNA chains in DNA/polyethylene glycol/monovalent salt aqueous solutions