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Communications: Can one identify nonequilibrium in a three-state system by analyzing two-state trajectories?
4.P. Selvin and T. Ha, Single Molecule Techniques (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 2007).
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For a three-state Markov system in a stationary state, we discuss whether, on the basis of data obtained from effective two-state (or on-off) trajectories, it is possible to discriminate between an equilibrium state and a nonequilibrium steady state. By calculating the full phase diagram we identify a large region where such data will be consistent only with nonequilibrium conditions. This regime is considerably larger than the region with oscillatory relaxation, which has previously been identified as a sufficient criterion for nonequilibrium.
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