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Compartmentalization and delivery via asymmetric copolymer monolayers with swollen or inverse swollen micelles
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10.1063/1.3340403
/content/aip/journal/jcp/132/9/10.1063/1.3340403
http://aip.metastore.ingenta.com/content/aip/journal/jcp/132/9/10.1063/1.3340403
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

An asymmetric A-B copolymer monolayer formed at interfaces that separate immiscible C and B matrix-components (center cartoon) in the presence of attractive interactions among A-block and C-matrix units can lead to two types of emulsions present in either one or both of the matrices coexisting with the adsorbed copolymer monolayer: inverted or crew-cut swollen micelles (left cartoon) and swollen micelles (right cartoon). Swollen micelles in the B-matrix phase (right cartoon) results in systems with highly asymmetric copolymers. Meanwhile in ternary systems with less asymmetric copolymers, a monolayer collapse transition induces the formation of inverse swollen micelles in the C-matrix phase (left cartoon). The process occurs via budding and fission from the metastable copolymer monolayer at the interface between the C-matrix and B-matrix components. These inverse swollen micelles permit the encapsulation of more cargo for delivery than conventional swollen micelles.

Image of FIG. 2.
FIG. 2.

Phase diagram showing the regions where swollen micelles or inverse swollen micelles are in equilibrium with the adsorbed copolymer monolayer at the interface between the matrix and phases at fixed interaction parameter, defined in Eq. (1), and copolymer concentration . Filled circles define molecular parameters required to generate stable swollen micelles. Filled squares define molecular parameters required to generate stable inverse swollen micelles. Crosses define molecular parameters where free copolymers in the bulk phase are in equilibrium with adsorbed copolymer monolayer at the interface.

Image of FIG. 3.
FIG. 3.

(a) The time evolution of the interfacial tension calculated by averaging instant interfacial tension over the sub-run of the length of 20 time steps , and (b) the typical configuration sequences for a system with and [see Eq. (1)] and copolymer concentration . The big black dot in (a) indicates the value of at time zero. For clarification, there is a break in the Y axis of (a). In (b), the copolymers stabilize swollen micelles in the matrix in the presence of adsorbed copolymer monolayer at the interface between the matrix and phases. For clarification, is shown in green, block in orange, and the matrix components and blocks are not shown. The starting configuration is described in the text.

Image of FIG. 4.
FIG. 4.

(a) The time evolution of the interfacial tension calculated by averaging instant interfacial tension over the sub-un of the length of 20 time steps , and (b) the typical configuration sequences for a system with and [see Eq. (1)] and copolymer concentration . In (b), the copolymers stabilize inverse swollen micelles in the matrix in the presence of adsorbed copolymer monolayer at the interface between the matrix and phases. For clarification, the same configuration is shown by the left and right images with different sets of monomers. Here is shown in green, block in orange, in red and block in blue. The remaining details is the same as Fig. 3.

Image of FIG. 5.
FIG. 5.

The interfacial copolymer excess , as function of the interaction parameters defined in Eq. (1) for the studied ternary blends at fixed and copolymer concentration .

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/content/aip/journal/jcp/132/9/10.1063/1.3340403
2010-03-02
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Compartmentalization and delivery via asymmetric copolymer monolayers with swollen or inverse swollen micelles
http://aip.metastore.ingenta.com/content/aip/journal/jcp/132/9/10.1063/1.3340403
10.1063/1.3340403
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