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Flat pancake distant dipolar fields for enhancement of intermolecular multiple-quantum coherence signals
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10.1063/1.3690110
/content/aip/journal/jcp/136/9/10.1063/1.3690110
http://aip.metastore.ingenta.com/content/aip/journal/jcp/136/9/10.1063/1.3690110

Figures

Image of FIG. 1.
FIG. 1.

Sketch of localized DDF model for a cylindrical sample. (a) Equilibrium magnetization; (b) the magnetization of a slice at the center of sample is inverted after an adiabatic inversion pulse; (c) equivalent model of (b) as a sum of the original sample with equilibrium magnetization and a flat pancake sample with two folds inverted magnetization.

Image of FIG. 2.
FIG. 2.

Pulse sequences used for iMQC imaging. (a) Original CRAZED sequence and (b) LED sequence. The first pulse in (b) is an adiabatic inversion RF pulse.

Image of FIG. 3.
FIG. 3.

(a) Variation of theoretical signal intensity ratio of the LED sequence relative to the conventional CRAZED sequence with T 2 for ideal spherical liquid phantoms with different equilibrium magnetization; Experimental (b) and simulated (c) relative signal intensities of a cylinder DMSO phantom at different echo time for the CRAZED, ZEBRA, and LED sequences.

Image of FIG. 4.
FIG. 4.

Variations of experimental and simulated signal intensity ratios of the LED sequence relative to the conventional CRAZED sequence with inverted slice thickness for a spherical water phantom under the fixed imaging slice thickness of 0.5 mm.

Image of FIG. 5.
FIG. 5.

Theoretical, simulated, and experimental results for a spherical water phantom with a diameter of 3.4 cm under different inverted slice thickness. (a) Theoretical DDF amplification factor; (b) simulated signal intensity ratio; (c) experimental signal intensity ratio. The inverted slice is parallel to the XY plane with its center coinciding with the center of sample model, and the curves are drawn through the center of inverted slice along the Y direction.

Image of FIG. 6.
FIG. 6.

Experimental (a)–(e) and simulated (f)–(j) MR images of a spherical water phantom from the LED sequence. (a) and (f) DDF modulation along the Z direction; (b) and (g) DDF modulation along the X direction; (c) and (h) DDF modulation along the magic-angle direction; (d) and (i) DDF modulation along the X direction with three parallel inverted slices; (e) and (j) DDF modulation along the X and Y directions; (k) experimental and simulated signal profiles perpendicular to the inverted slice obtained from (b) and (g).

Image of FIG. 7.
FIG. 7.

In vivo mouse brain MR images with 1 mm inverted and imaging slice thickness from the LED sequence (a) and (d), the ZEBRA sequence (b) and (e), and the CRAZED sequence (c) and (f). (a)–(c) DDF modulation along the Z direction; (d)–(f) DDF modulation along the magic-angle direction; (g) the profile curves of (a)–(f) along the horizontal direction.

Image of FIG. 8.
FIG. 8.

In vivo mouse brain MR images from the LED and CRAZED sequences with 2 mm inverted and imaging slice thickness. (a) Image from LED sequence with DDF along the Z direction; (b) the same as (a) but the DDF is along the magic-angle direction; (c) image from the CRAZED sequence with the CSGs along the Z direction; (d) the same as (c) but the CSGs are along the magic-angle direction; and (e) the profile curves corresponding to (a)–(d) along the horizontal direction.

Image of FIG. 9.
FIG. 9.

Results of multi-slice LED sequence relative to the CRAZED sequence for a spherical water phantom. (a) Calculated variation of DDF amplification factor with relative slice interval; (b) experimental signal intensity ratio vs relative slice intervals. Relative slice interval is defined as slice interval/inverted slice thickness.

Tables

Generic image for table
Table I.

The TE values for maximal signal intensities and the maximal relative signal intensities for the CRAZED, ZEBRA, and LED sequences obtained from Figs. 3(b) and 3(c).

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/content/aip/journal/jcp/136/9/10.1063/1.3690110
2012-03-01
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Flat pancake distant dipolar fields for enhancement of intermolecular multiple-quantum coherence signals
http://aip.metastore.ingenta.com/content/aip/journal/jcp/136/9/10.1063/1.3690110
10.1063/1.3690110
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