No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
Communication: Probing the absolute configuration of chiral molecules at aqueous interfaces
5.P. Herwig, K. Zawatzky, M. Grieser, O. Heber, B. Jordon-Thaden, C. Krantz, O. Novotny, R. Repnow, V. Schurig, D. Schwalm, Z. Vager, A. Wolf, O. Trapp, and H. Kreckel, Science 342, 1084 (2013).
6.M. Pitzer, M. Kunitski, A. S. Johnson, T. Jahnke, H. Sann, F. Sturm, L. P. H. Schmidt, H. Schmidt-Böcking, R. Dörner, J. Stohner, J. Kiedrowski, M. Reggelin, S. Marquardt, A. Schießer, R. Berger, and M. S. Schöffler, Science 341, 1096 (2013).
7.K. Zawatzky, P. Herwig, M. Grieser, O. Heber, B. Jordon-Thaden, C. Krantz, O. Novotny, R. Repnow, V. Schurig, D. Schwalm, Z. Vager, A. Wolf, H. Kreckel, and O. Trapp, Chem.–Eur. J. 20, 5555 (2014).
13.S. R. Domingos, A. Huerta-Viga, L. Baij, S. Amirjalayer, D. A. E. Dunnebier, A. J. C. Walters, M. Finger, L. A. Nafie, B. de Bruin, W. J. Buma, and S. Woutersen, J. Am. Chem. Soc. 136, 3530 (2014).
See supplementary material at http://dx.doi.org/10.1063/1.4936403
for a description of the synthesis of (L)- and (D)-AFP1, characterization of the products via mass spectrometry and temperature-dependent UV-CD-spectroscopy, and a detailed description of the determination fo the phase of ESFG
Article metrics loading...
We demonstrate that the enantiomers of chiralmacromolecules at an aqueous interface can be distinguished with monolayer sensitivity using heterodyne-detected vibrational sum-frequency generation (VSFG). We perform VSFG spectroscopy with a polarization combination that selectively probes chiral molecular structures. By using frequencies far detuned from electronic resonances, we probe the chiral macromolecular structures with high surface specificity. The phase of the sum-frequency light generated by the chiral molecules is determined using heterodyne detection. With this approach, we can distinguish right-handed and left-handed helical peptides at a water-air interface. We thus show that heterodyne-detected VSFG is sensitive to the absolute configuration of complex, interfacial macromolecules and has the potential to determine the absolute configuration of enantiomers at interfaces.
Full text loading...
Most read this month