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1.
1.A. Cruz and B. G. Green, Nature 403, 889 (2000).
http://dx.doi.org/10.1038/35002581
2.
2.A. M. Calvino, Physiol. Behav. 36, 1021 (1986).
http://dx.doi.org/10.1016/0031-9384(86)90474-9
3.
3.S. S. Schiffman, E. A. Sattely-Miller, B. G. Graham, J. L. Bennett, B. J. Booth, N. Desai, and I. Bishay, Physiol. Behav. 68, 469 (2000).
http://dx.doi.org/10.1016/S0031-9384(99)00205-X
4.
4.L. M. Bartoshuk, K. Rennert, J. Rodin, and J. C. Stevens, Physiol. Behav. 28, 905 (1982).
http://dx.doi.org/10.1016/0031-9384(82)90212-8
5.
5.B. G. Green and S. P. Frankmann, Physiol. Behav. 43, 515 (1988).
http://dx.doi.org/10.1016/0031-9384(88)90127-8
6.
6.J. C. Fry, N. Yurttas, and K. Biermann, J. Food Sci. 76, S545 (2011).
http://dx.doi.org/10.1111/j.1750-3841.2011.02414.x
7.
7.B. Lindemann, Physiol. Rev. 76, 718 (1996), http://www.ncbi.nlm.nih.gov/pubmed/8757787.
8.
8.M. A. Hoon, E. Adler, J. Lindemeier, J. F. Battey, N. J. P. Ryba, and C. S. Zuker, Cell 96, 541 (1999).
http://dx.doi.org/10.1016/S0092-8674(00)80658-3
9.
9.E. Adler, M. A. Hoon, K. L. Mueller, J. Chandrashekar, N. J. P. Ryba, and C. S. Zuker, Cell 100, 693 (2000).
http://dx.doi.org/10.1016/S0092-8674(00)80705-9
10.
10.G. Nelson, J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao, N. J. P. Ryba, and C. S. Zuker, Nature 416, 199 (2002).
http://dx.doi.org/10.1038/nature726
11.
11.G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. P. Ryba, and C. S. Zuker, Cell 106, 381 (2001).
http://dx.doi.org/10.1016/S0092-8674(01)00451-2
12.
12.G. Q. Zhao, Y. Zhang, M. A. Hoon, J. Chandrashekar, I. Erlenbach, N. J. P. Ryba, and C. S. Zuker, Cell 115, 255 (2003).
http://dx.doi.org/10.1016/S0092-8674(03)00844-4
13.
13.M. Behrens, W. Meyerhof, C. Hellfritsch, and T. Hofmann, Angew. Chem., Int. Ed. 50, 2220 (2011).
http://dx.doi.org/10.1002/anie.201002094
14.
14.J.-M. Tinti and C. Nofre, in Sweeteners Discovery, Molecular Design and Chemoreception, edited by D. E. Walters, F. T. Orthoefer, and G. DuBois (American Chemical Society, Washington, 1991).
15.
15.R. S. Shallenberger and T. E. Acree, Nature 206, 480 (1967).
http://dx.doi.org/10.1038/216480a0
16.
16.L. B. Kier, J. Pharm. Sci. 61, 1394 (1972).
http://dx.doi.org/10.1002/jps.2600610910
17.
17.D. Cremer and J. A. Pople, J. Am. Chem. Soc. 97, 1354 (1975).
http://dx.doi.org/10.1021/ja00839a011
18.
18.V. S. P. Chaturvedula and I. Prakash, Eur. J. Med. Plants 2, 57 (2012).
http://dx.doi.org/10.9734/EJMP/2012/1009
19.
19.M. Upreti, J. P. Smit, E. J. Hagen, V. N. Smolenskaya, and I. Prakash, Cryst. Growth Des. 12, 990 (2012).
http://dx.doi.org/10.1021/cg201463g
20.
20.M. P. Allen and D. J. Tildesley, Computer Simulation of Liquids (Oxford University Press, USA, 1989).
21.
21.D. Frenkel and B. Smit, Understanding Molecular Simulation (Academic Press, 2002).
22.
22.X. Biarnés, A. Ardèvol, A. Planas, C. Rovira, A. Laio, and M. Parrinello, J. Am. Chem. Soc. 129, 10686 (2007).
http://dx.doi.org/10.1021/ja068411o
23.
23.See supplementary material at http://dx.doi.org/10.1063/1.4937946 for details of sensory analysis, NMR experiments, molecular simulation calculations, and crystallographic information.[Supplementary Material]
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/content/aip/journal/jcp/143/24/10.1063/1.4937946
2015-12-22
2016-12-06

Abstract

The diterpene steviol glycoside, rebaudioside A, is a natural high potency non-caloric sweetener extracted from the leaves of . This compound shows a parabolic change in sweet taste intensity with temperature which contrasts with the general finding for other synthetic or natural sweeteners whose sweet taste increases with temperature. The nonmonotonic taste behavior was determined by sensory analysis using large taste panels. The conformational landscape of rebaudioside A was established at a range of temperatures by means of nuclear magnetic resonance and molecular dynamics simulation. The relationship between various conformations and the observed sweetness of rebaudioside A is described.

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