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1.M. Mammen, S. K. Choi, and G. M. Whitesides, Angew. Chem., Int. Ed. 37, 2754 (1998).<2754::AID-ANIE2754>3.0.CO;2-3
2.F. J. Martinez-Veracoechea and D. Frenkel, Proc. Natl. Acad. Sci. U. S. A. 108, 10963 (2011).
3.L. D. Michele and E. Eiser, Phys. Chem. Chem. Phys. 15, 3115 (2013).
4.C. T. Varner, T. Rosen, J. T. Martin, and R. S. Kane, Biomacromolecules 16, 43 (2015).
5.P. Varilly, S. Angioletti-Uberti, B. M. Mognetti, and D. Frenkel, J. Chem. Phys. 137, 094108 (2012).
6.S. Angioletti-Uberti, P. Varilly, B. M. Mognetti, A. V. Tkachenko, and D. Frenkel, J. Chem. Phys. 138, 021102 (2013).
7.See supplementary material at for a derivation of the valence-limited interaction theory (VLIT) considering a multivalent particle with chemically-indistinct ligands.[Supplementary Material]
8.S. Angioletti-Uberti, P. Varilly, B. M. Mognetti, and D. Frenkel, Phys. Rev. Lett. 113, 128303 (2014).
9.J. Vonnemann, C. Sieben, C. Wolff, K. Ludwig, C. Boettcher, A. Herrmann, and R. Haag, Nanoscale 6, 2353 (2014).

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We present a simple yet accurate numerical approach to compute the free energy of binding of multivalent objects on a receptor-coated surface. The method correctly accounts for the fact that one ligand can bind to at most one receptor. The numerical approach is based on a saddle-point approximation to the computation of a complex residue. We compare our theory with the powerful Valence-Limited InteractionTheory (VLIT) [P. Varilly , J. Chem. Phys. , 094108 (2012); S. Angioletti-Uberti , . , 021102 (2013)] and find excellent agreement in the regime where that theory is expected to work. However, the present approach even works for low receptor/ligand densities, where VLIT breaks down.


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