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The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle
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10.1063/1.3633337
/content/aip/journal/pof2/23/9/10.1063/1.3633337
http://aip.metastore.ingenta.com/content/aip/journal/pof2/23/9/10.1063/1.3633337

Figures

Image of FIG. 1.
FIG. 1.

(Color online) Definition sketch of the vaginal canal. The introitus is to the right. Vaginal fluid fluxes and squeezing forces are effective for both of the vaginal surfaces.

Image of FIG. 2.
FIG. 2.

Shape of domains. Left domain represents the physical domain. Right domain represents mapped domain by y = h(x, t)ζ.

Image of FIG. 3.
FIG. 3.

(Color online) Height profile of boluses of homogenously diluted gel, at 30 min.

Image of FIG. 4.
FIG. 4.

(Color online) Coated area of homogenously diluted gel vs. time.

Image of FIG. 5.
FIG. 5.

(Color online) Shear stress on the wall for homogenously diluted gel at 30 min.

Image of FIG. 6.
FIG. 6.

(Color online) Effective viscosity of homogenously diluted gel on the wall at 30 min.

Image of FIG. 7.
FIG. 7.

(Color online) Coating area of the gel on the surface for a d  = 0, 1, 2, 4, and 10 (q = 1 × 10–8 m/s and D = 10–6 cm2/s).

Image of FIG. 8.
FIG. 8.

(Color online) Height profile of bolus at 2 h for q = 0 m/s, 1 × 10–9 m/s, 5 × 10–9 m/s, and 1 × 10–8 m/s (D = 10–6 cm2/s).

Image of FIG. 9.
FIG. 9.

(Color online) Coating area of the gel on the surface for q = 0 m/s, 1 × 10–9 m/s, 5 × 10–9 m/s, and 1 × 10–8 m/s (D = 10–6 cm2/s).

Image of FIG. 10.
FIG. 10.

(Color online) Height profile of bolus at 2 h for q = 0 m/s, 1 × 10–9 m/s, 5 × 10–9 m/s, and 1 × 10–8 m/s (D = 10–5 cm2/s).

Image of FIG. 11.
FIG. 11.

(Color online) Coating area of the gel on the surface for q = 0 m/s, 1 × 10–9 m/s, 5 × 10–9 m/s, and 1 × 10–8 m/s (D = 10–5 cm2/s).

Image of FIG. 12.
FIG. 12.

(D = 10–6 cm2/s). Contour plot for volume fraction of vaginal fluid at 1 min, 5 min, 30 min, and 2 h (top to bottom). Note different contour levels in different panels.

Image of FIG. 13.
FIG. 13.

(D = 10–5 cm2/s). Contour plot for volume fraction of vaginal fluid at 1 min, 5 min, 30 min, and 2 h (top to bottom). Note different contour levels in different panels.

Image of FIG. 14.
FIG. 14.

(Color online) Coating area of the gel on the surface for q = 0 m/s (dashed-dot), 1 × 10–9 m/s, 5 × 10–9 m/s, 1 × 10–8 m/s (D = 10–5 cm2/s (dashed), and 10–6 cm2/s (solid)).

Tables

Generic image for table
Table I.

Parameters of Carreau-like model for homogeneously diluted AO gel by viscometric experiments.

Generic image for table
Table II.

(D 0 = 10 6 cm2/s) The constant wall flux of vaginal fluid. Mean volume fractions are obtained at 1 min. MVF1 is obtained from numerical solution of Eq. (8). MVF2 is calculated by Eq. (12).

Generic image for table
Table III.

(D 0 = 10 6 cm2/s) Averages of velocity profiles at x = 5 cm and averages of effective viscosities at 1 min and final coating areas.

Generic image for table
Table IV.

(D 0 = 10 5 cm2/s) Averages of velocity profiles at x = 5 cm and averages of effective viscosities at 1 min and final coating areas.

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/content/aip/journal/pof2/23/9/10.1063/1.3633337
2011-09-15
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle
http://aip.metastore.ingenta.com/content/aip/journal/pof2/23/9/10.1063/1.3633337
10.1063/1.3633337
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