1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Two- and three-dimensional modeling and optimization applied to the design of a fast hydrodynamic focusing microfluidic mixer for protein folding
Rent:
Rent this article for
USD
10.1063/1.4793612
/content/aip/journal/pof2/25/3/10.1063/1.4793612
http://aip.metastore.ingenta.com/content/aip/journal/pof2/25/3/10.1063/1.4793612

Figures

Image of FIG. 1.
FIG. 1.

Typical domain representation of the microfluidic mixer geometry considering the 3D model: in dark gray we represent the domain Ω used for numerical simulations. The geometry's symmetry planes are highlighted and labeled.

Image of FIG. 2.
FIG. 2.

Typical representation of the domain Ω and parameterization of the microfluidic mixer considered for the optimization process.

Image of FIG. 3.
FIG. 3.

Mixing times of the 100 microfluidic mixers (called Scenarios), randomly generated during the 2D versus 3D comparison process and sorted considering the 2D mixing time, as computed when considering (a) the 2D model and (b) the 3D model.

Image of FIG. 4.
FIG. 4.

Optimized mixer simulated with the 2D model: (a) shape of the optimized mixer with a superposed color plot of the denaturant concentration distribution and (b) the time evolution of the denaturant concentration of a particle in the symmetry streamline.

Image of FIG. 5.
FIG. 5.

Comparison of the solutions obtained in the mixing region with the optimized mixer considering the 3D model (subfigures (a) and (c)) and the 2D model (subfigures (b) and (d)). (a) and (b) show denaturant concentration distributions while (c) and (d) plot velocity amplitude distributions in the symmetric plane = 0 μm. For the 3D case, the figure also shows, in the inset detail views, the X-Z plane slices of the concentration and velocity amplitude distributions at the plane defined by y = 16.5 μm (represented with a horizontal black lines).

Image of FIG. 6.
FIG. 6.

Sample results from the optimized mixer design as simulated with the 3D model. Isometric views of the shape of the optimized mixer are shown, considering the computational domain Ω defined in Sec. II A , with representation of (a) the concentration distribution, and (b) the velocity amplitude distribution.

Image of FIG. 7.
FIG. 7.

Selected streamlines (gray lines) generated by considering the velocity field obtained with the 3D model in the plane = 0 μm.

Tables

Generic image for table
Table I.

Mean, minimum, and maximum percent variation (%) of the mixing time, concentration distribution in the plane = 0 μm and velocity field in the plane = 0 μm obtained when considering the 100 microfluidic mixers randomly generated during the 2D-3D comparison experiments detailed in Sec. III B .

Generic image for table
Table II.

Values of the optimized microfluidic mixer parameters presented in Sec. IV C .

Generic image for table
Table III.

Mean, minimum, and maximum percent variation (%) in the mixing time obtained by considering the 3D model and by perturbing randomly all the parameters of ϕ with a maximum amplitude of 1%, 5%, 10%, and 20% of their initial value.

Loading

Article metrics loading...

/content/aip/journal/pof2/25/3/10.1063/1.4793612
2013-03-06
2014-04-18
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Two- and three-dimensional modeling and optimization applied to the design of a fast hydrodynamic focusing microfluidic mixer for protein folding
http://aip.metastore.ingenta.com/content/aip/journal/pof2/25/3/10.1063/1.4793612
10.1063/1.4793612
SEARCH_EXPAND_ITEM