1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Micromachined force sensors for the study of cell mechanics
Rent:
Rent this article for
USD
10.1063/1.1863792
/content/aip/journal/rsi/76/4/10.1063/1.1863792
http://aip.metastore.ingenta.com/content/aip/journal/rsi/76/4/10.1063/1.1863792
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

(Color online) Schematic (a) and SEM image (b) of a mechanical force sensor.

Image of FIG. 2.
FIG. 2.

(Color online) SCREAM process used to fabricate the sensor.

Image of FIG. 3.
FIG. 3.

Experimental system and the sensor to measure the cell force response.

Image of FIG. 4.
FIG. 4.

Morphological changes of two cells due to mechanical disturbance of the sensor probe. (a) Right after the probe indented a monkey kidney fibroblast (MKF); and (b) after (a). (c) Right after the probe indented an MKF; (d) and (e) seven min and after (c), respectively.

Image of FIG. 5.
FIG. 5.

Force response of an MKF due to large lateral indentation. (a) Force response. (b)–(f) Representative phase contrast images.

Image of FIG. 6.
FIG. 6.

Stretch force response of an MKF with a small adhesion site with the sensor probe. (a) Force response. (b)–(f) Representative phase contrast images.

Image of FIG. 7.
FIG. 7.

Stretch force response of an MKF with a large adhesion site with the sensor probe. (a) Force response. (b)–(f) Representative phase contrast images.

Image of FIG. 8.
FIG. 8.

(Color online) (a) Two-component force sensor. (b) Cell deformation vector. (c) Force response vector. (d)–(g) Representative phase contrast images.

Image of FIG. 9.
FIG. 9.

(Color online) Reducing the stiffness of the force sensor by serially adding the sensor beams.

Image of FIG. 10.
FIG. 10.

Calibrating the stiffness of a softer cantilever by a precalibrated AFM cantilever.

Loading

Article metrics loading...

/content/aip/journal/rsi/76/4/10.1063/1.1863792
2005-03-16
2014-04-18
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Micromachined force sensors for the study of cell mechanics
http://aip.metastore.ingenta.com/content/aip/journal/rsi/76/4/10.1063/1.1863792
10.1063/1.1863792
SEARCH_EXPAND_ITEM