Schematic representation of (a) conventional and (b) multiple-layer sample preparation for MALDI-TOFMS.
(Color online) (a) Optical microscopy pictures of layers of different matrices crystallized from different solvents. (b) The corresponding MALDI-TOFMS signal intensities for a poly(ethylene glycol) standard . All MALDI spectra for this experiment were recorded with the same instrument settings for comparison reasons (, ).
(Color online) Inside view of the Chemspeed ASW 2000 automated synthesizer with reactor blocks installed and MALDI target in the specially designed holder.
(Color online) (a) Picture of the ink-jet printer with a microtiter plate containing the samples and the MALDI target. (b) A defined matrix spot resulting from the printing.
(Color online) (a) Picture of a MALDI sample target. (b) Schematic representation of the target indicating the deposition of more than 4000 samples on one plate due to the small spot size of ink-jet printed samples.
MALDI-TOFMS monitoring of a RAFT polymerization in time: Spectra obtained from the automated spotting of the synthesized poly(methyl methacrylate) polymers at different reaction times. The insert shows the peak molecular weight (obtained from MALDI TOFMS spectra) as function of the reaction time (taken from Ref. 30).
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