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Photoacoustic imaging in biomedicine
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    Minghua Xu1,a) and Lihong V. Wang1,b)
    + View Affiliations - Hide Affiliations
    1 Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, Texas 77843-3120
    a) Present address: Abramson Family Cancer Research Institute at the University of Pennsylvania School of Medicine, Room 627 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6160.
    b) Author to whom all correspondence should be addressed; also at the Department of Biomedical Engineering at Washington University in St. Louis, One Brookings Drive, Campus Box 1097, St. Louis, MO 63130-4899 as of June 2006; FAX: 979-845-4450; electronic mails: lwang@tamu.edu and lwang@bme.tamu.edu; URL: http://oilab.tamu.edu
    Rev. Sci. Instrum. 77, 041101 (2006); http://dx.doi.org/10.1063/1.2195024
View: Figures


Image of FIG. 1.
FIG. 1.

Diagram of initial pressure distribution.

Image of FIG. 2.
FIG. 2.

(a) Diagram of thermoacoustic scanning tomography. (b) Thermoacoustic image of a phantom sample: a piece of muscle buried in several layers of fat.

Image of FIG. 3.
FIG. 3.

(a) Diagram of a bright-field confocal photoacoustic microscope in the backward detection mode. (b) Schematic of the photoacoustic sensor of a dark-field reflection-mode photoacoustic microscope. (c) Photoacoustic image of vascular distribution in rat skin.

Image of FIG. 4.
FIG. 4.

Acoustic lens system with a focal length of .

Image of FIG. 5.
FIG. 5.

Diagram of photoacoustic measurement at .

Image of FIG. 6.
FIG. 6.

Diagram of measurement configurations: (a) spherical geometry, (b) planar geometry, and (c) cylindrical geometry.

Image of FIG. 7.
FIG. 7.

Measurement surface enclosing: (a) and (b). Diagram of detection region: (c) and (d).

Image of FIG. 8.
FIG. 8.

Diagram of photoacoustic measurement at with a large planar detector.

Image of FIG. 9.
FIG. 9.

rf penetration depths in various tissues.

Image of FIG. 10.
FIG. 10.

(a) Side view schematic of a breast imager with spherical scans. (b) TCT image of a normal breast (Courtesy of OptoSonics, Inc.).

Image of FIG. 11.
FIG. 11.

(a) Diagram of circular scan. (b) Reconstructed thermoacoustic image. (c) TAT image of a breast mastectomy specimen (Ref. 106).

Image of FIG. 12.
FIG. 12.

(a) Side view schematic of optoacoustic imaging of a breast using an arc array. (b) Noninvasive optoacoustic image of a human breast containing a tumor. (c) Diagram of the photoacoustic mammoscope.

Image of FIG. 13.
FIG. 13.

(a) Diagram of photoacoustic imaging system for small animals in a circular or cylindrical scan. (b) A cross-sectional photoacoustic image of a rat brain. RH, right cerebral hemisphere; LH, left cerebral hemisphere; L, lesion; MCA, middle cerebral artery (Ref. 116).

Image of FIG. 14.
FIG. 14.

Diagram of photoacoustic imaging system for small animals using arc array.

Image of FIG. 15.
FIG. 15.

Noninvasive functional photoacoustic image corresponding to the left-side whisker stimulations, acquired with the skin and skull intact (Ref. 116).


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Photoacoustic imaging in biomedicine