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A novel pressure-driven piezodispenser for nanoliter volumes
1.D. R. Meldrum, M. R. Holl, C. H. Fisher, M. S. Saini, S. K. McGuire, T. T. H. Ren, W. Pence, S. E. Moody, D. L. Cunningham, D. A. Donaldson, and P. J. Wiktor, IEEE International Conference on Automation Science and Engineering, 2005.
3.K. K. Tan and A. S. Putra, IEEE International Conference on Industrial Technology, December 2005.
6.Y. Liu, L. Chen, and L. Sun, IEEE International Conference on Mechatronics and Automation, 2007.
7.W. D. Niles and P. J. Coassin, Assay and Drug Development Technologies 3, 189 (2005).
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A successful dispensing device has been built for use in biotechnology applications requiring nanoliter volume liquid transfer. Air pressure is used as the primary driving force and is controlled via a high speed miniature solenoid valve as opposed to many existing systems that use a valve in line with constantly pressurized fluid to start and stop the dispensing action. This automated pressure-driven system is used to improve a typical piezodriven microdispenser. The resulting system is much less prone to failures resulting from air entrainment and can dispense much higher viscosity fluids than the microdispenser alone.
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