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A benchtop, ultrafast infrared spectroscopic imaging system for biomedical applications
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10.1063/1.3262499
/content/aip/journal/rsi/80/12/10.1063/1.3262499
http://aip.metastore.ingenta.com/content/aip/journal/rsi/80/12/10.1063/1.3262499
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Schematic of the tuneable IR source built for the imaging system. A laser, based on the transition, is configured to produce 100 ps pulses. After amplification these are intense enough to generate usefully intense “optical parametric generation” pulses after a double pass through a nonlinear crystal. The wavelengths of the OPG output pulses are determined by momentum-matching constraints inside the nonlinear crystal, so they can be selected at will by choosing its angle under computer control.

Image of FIG. 2.
FIG. 2.

Upper plot: Pulse energy histogram of the laser set to a mean output of . Lower plot: Histogram of OPG idler pulse energies at a wavelength of and a nominal pulse energy of .

Image of FIG. 3.
FIG. 3.

Schematic of the optical setup.

Image of FIG. 4.
FIG. 4.

Plot of the variation in OPG linewidth as it is tuned through the mid-IR.

Image of FIG. 5.
FIG. 5.

(a) The standard USAF 1915 resolution test sample used to calibrate the IR imager. (b) Transmission mode images of the chart recorded with the JASCO-IRT 30 microscope and the CEDIP FPA camera using illumination from the OPG laser source. (i) Picture is of line pairs in group 4 on the chart where elements 4, 5, and 6 (G4-E4,E5, and E6) are resolved by visual inspection. (ii) Picture is of line pairs in group 5 in the chart where elements 4, 5, and 6 (G5-E4,E5, and E6) are resolved by visual inspection. (iii) Picture is of line pairs in group 6 on the chart where elements 1 and 2 (G6-E1,E2) are resolved by visual inspection.

Image of FIG. 6.
FIG. 6.

(a) Reflection mode image of a copper electron microscopy grid taken with a single 100 ps pulse from the OPG. (b) Intensity scan across the line in the image, evidencing an unsmoothed SNR of and diffraction-limited spatial resolution.

Image of FIG. 7.
FIG. 7.

(a) Visible image of the test sample for chemical mapping tests. It consists of a variety of PMMA shapes deposited on a silicon substrate by photolithography which we were able to map in a single 100 ps shot of OPG light, in the specular reflectance mode (b). The line scan (c) reveals the degree to which the grid structure (with a pitch) in the upper left of the image has been spatially resolved.

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/content/aip/journal/rsi/80/12/10.1063/1.3262499
2009-12-07
2014-04-23
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: A benchtop, ultrafast infrared spectroscopic imaging system for biomedical applications
http://aip.metastore.ingenta.com/content/aip/journal/rsi/80/12/10.1063/1.3262499
10.1063/1.3262499
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