Scheme of the feedback controlled system, as proposed for future studies. Additional feedback parameters may be obtained from medium analysis (e.g., level in the medium or lactate consumption). Additional control parameters may be growth factors, which are added to the medium or remaining culture time.
Scheme of the MSU including culture chamber and control unit.
Photographs of the MSU and the culture chambers. One culture chamber as it is mounted in the MSU inside a sterile laminar flow bench (a). Close up of the chamber in the MSU (b). Twelve culture chambers inside an incubator and connected to medium circulation tubes (c).
Displacement validation: (a) Bode plot illustrating the amplification of the measured displacement amplitude in relation to the commanded displacement amplitude for commanded amplitudes of 80 and . (b) THD as a function of the commanded sine wave’s frequency for commanded amplitudes of 80 and . (c) Graph illustrating the measured displacement at 10 Hz with an amplitude of .
Force-displacement plots for two different springs as measured on a Zwick material testing machine and on the custom-made MSU. The axis is without a scale because the curves obtained from the two different machines were shifted in direction to each other to illustrate the parallel force-displacement measurement. The two noisier curves ( and ) were measured using the custom-made MSU.
3D images of human bone biopsy specimen as measured by using (a) the original scanning vial and (b) the custom-made culture chamber.
Commanded and measured displacement to test the displacement accuracy and precision.
Morphological parameters of bone biopsy specimen upon scanning as measured in original scanning vial vs custom-made culture chamber (-value as determined by Student’s t-test).
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