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Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser
13., , where , , and are the refractive indices of the microsphere (1.45), aqueous medium (1.33), and polystyrene (1.59); for polystyrene nanoparticles .
14.R. M. Corless, D. J. Jeffrey, and D. E. Knuth, Proceedings of the 1997 International Symposium on Symbolic and Algebraic Computation, Maui, HI (ACM, New York, 1997), pp. 197–204.
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We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery modebiosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise associated with the use of the DFB-PPLN device.
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