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Integrated automated nanomanipulation and real-time cellular surface imaging for mechanical properties characterization
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10.1063/1.4757115
/content/aip/journal/rsi/83/10/10.1063/1.4757115
http://aip.metastore.ingenta.com/content/aip/journal/rsi/83/10/10.1063/1.4757115
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

TEM image of the human corneal cell.

Image of FIG. 2.
FIG. 2.

A schematic picture of the proposed laserless cellular surface imaging platform.

Image of FIG. 3.
FIG. 3.

A lumped-parameters model of the microcantilever.

Image of FIG. 4.
FIG. 4.

A distributed-parameters model of the piezoresistive microcantilever (microcantilever's bending calculation for determining the tip displacement).

Image of FIG. 5.
FIG. 5.

Frequency response (amplitude and phase) of the distributed system in response to the variation of the sample stiffness coefficient (k s ).

Image of FIG. 6.
FIG. 6.

Frequency response (amplitude and phase) of the distributed system in response to the variation of the sample damping coefficient (c s ).

Image of FIG. 7.
FIG. 7.

Attachment of the sample to the force sensor's tip.40

Image of FIG. 8.
FIG. 8.

Experimental setup of the MM3A® with the FMS-EM force sensing module.

Image of FIG. 9.
FIG. 9.

NanoControl unit.

Image of FIG. 10.
FIG. 10.

Front and back view of the force measurement system (FMS), FMS plug-in holder (bottom left), and FMS adaptor (bottom right).

Image of FIG. 11.
FIG. 11.

Circuit of the force measurement system.41

Image of FIG. 12.
FIG. 12.

Voltage-displacement calibration curve.

Image of FIG. 13.
FIG. 13.

Dehydrated corneal cell for the purpose of surface imaging.

Image of FIG. 14.
FIG. 14.

Open-loop discrete control for the cellular surface imaging using MM3A®.

Image of FIG. 15.
FIG. 15.

Nanotopography imaging of the human corneal cell above its nucleus.

Image of FIG. 16.
FIG. 16.

(a)–(h) Different experimental measurements of the height of the corneal cell.

Image of FIG. 17.
FIG. 17.

(a)–(c) Height of the corneal cell above its nucleus under three different experimental measurements.

Image of FIG. 18.
FIG. 18.

Experimental frequency spectrum of the piezoresistive microcantilever: (a) amplitude and (b) phase.

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/content/aip/journal/rsi/83/10/10.1063/1.4757115
2012-10-16
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Integrated automated nanomanipulation and real-time cellular surface imaging for mechanical properties characterization
http://aip.metastore.ingenta.com/content/aip/journal/rsi/83/10/10.1063/1.4757115
10.1063/1.4757115
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