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A polychromator-type near-infrared spectrometer with a high-sensitivity and high-resolution photodiode array detector for pharmaceutical process monitoring on the millisecond time scale
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10.1063/1.4790413
/content/aip/journal/rsi/84/2/10.1063/1.4790413
http://aip.metastore.ingenta.com/content/aip/journal/rsi/84/2/10.1063/1.4790413

Figures

Image of FIG. 1.
FIG. 1.

Part of the 640-element PDA.

Image of FIG. 2.
FIG. 2.

Block diagram of PDA: (A) 320-element charge amplifier array, (B) sample hold circuit, (C) shift register circuit, and (D) timing generator circuit. Two ROICs and one PDA are assembled by the wire bonding method.

Image of FIG. 3.
FIG. 3.

Outline view of photodiode array sensor.

Image of FIG. 4.
FIG. 4.

Plot of root mean square noise current of each pixel.

Image of FIG. 5.
FIG. 5.

Fiber interface model of P-NIRs equipped with diffuse reflectance probe.

Image of FIG. 6.
FIG. 6.

Direct interface model of P-NIRs. (A) Optical window through which the irradiating and the diffuse reflected light are transmitted.

Image of FIG. 7.
FIG. 7.

Spectroscopic analyzer configuration: (A) spectroscope with a PDA detector, (B) internal optical source, (C) 18-bit analog/digital convertor for signal conversion and CPU, (D) data interface, (E) power supply (battery and external source), and (F) optical fiber probe.

Image of FIG. 8.
FIG. 8.

Spectro-engine of P-NIRs: (A) collimator lens, (B) diffraction grating, (C) focusing lens, (D) mirror, and (E) 640-element PDA.

Image of FIG. 9.
FIG. 9.

Blending test setup.

Image of FIG. 10.
FIG. 10.

Second-derivative spectra of talc with different wavelength resolutions.

Image of FIG. 11.
FIG. 11.

DR-NIR spectra of the D-mannitol and talc during mixing.

Image of FIG. 12.
FIG. 12.

Second-derivative spectra of the D-mannitol and talc during mixing.

Image of FIG. 13.
FIG. 13.

Plots for standard deviation of the second-derivative absorbance at 1392, 1495, and 1580 nm versus time.

Tables

Generic image for table
Table I.

Specification of P-NIRs.

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/content/aip/journal/rsi/84/2/10.1063/1.4790413
2013-02-13
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: A polychromator-type near-infrared spectrometer with a high-sensitivity and high-resolution photodiode array detector for pharmaceutical process monitoring on the millisecond time scale
http://aip.metastore.ingenta.com/content/aip/journal/rsi/84/2/10.1063/1.4790413
10.1063/1.4790413
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