- Conference date: 15-17 January 2007
- Location: Shiga (Japan)
Far infrared Spectroscopy is a useful tool for probing the low frequency (picosecond) collective fluctuations in biological systems. If one considers that a chemical reaction in a cell takes place on a time scale of several hundred femtoseconds to a few picoseconds, it becomes clear that an understanding of the motion and relaxation mechanisms of the various biological molecules in the intracellular matrix on a similar time scale (corresponding to a frequency range of ∼10 – 200 cm−1) is essential in fully comprehending the underlying mechanisms defining cellular activity.
Both experimental and theoretical studies have indicated that both secondary structural changes and environmental conditions play an important role in determining reaction rates in both proteins and DNA. Therefore, the main focus of the talk will be to contrast the (intermolecular) collective fluctuations detected in the far‐infrared spectra of both protein and DNA systems, which are correlated with intermediate conformational states along the reaction pathway, with (intramolecular) changes observed in the secondary structure of the individual residues in these same systems with mid‐infrared spectroscopy.
- Biochemical reactions
- Enzyme kinetics
- Far infrared spectroscopy
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