- Conference date: 25–30 September 2007
- Location: Corfu (Greece)
Elementary products of radiation damaged DNA and RNA base pairs are investigated using density functional methods. Relative energies, pair dissociation energies, and bond dissociation energies of radicals of the AT, GC and AU base pairs are presented here. Such radicals may be produced by the direct or indirect consequences of radiation, low energy electrons (LEEs), or by reactions with OH radicals. The predicted energetic properties may facilitate the identification of radicals in present and future experiments and thus create possibilities for unraveling DNA and RNA damage mechanisms. The results obtained in this research show the relative ease with which some of the damaged base pairs can be unpaired. This in turn creates the possibility of single and double strand breaks (SSB and DSB).
MOST READ THIS MONTH
MOST CITED THIS MONTH
Article metrics loading...