Effect of polychromatic visible light on proliferation of tumor cells under conditions in vitro and in vivo—after implantation to experimental animals
- Conference date: 31 October–1 November 2008
- Location: Florence (Italy)
The question of the character of effect of visible and near infrared (IR) radiation of Sun and artificial sources on growth of malignant tumors remains open due to controversy and a relatively small amount of available data, which restricts use of this most important environmental and the efficient physiotherapeutic factors at various human pathological states and first of all at the rehabilitation of oncological patients after radical methods of cancer treatment (surgical removal of tumor, intensive medication and radiation therapy), when immunomodulatory antiinflamatory, wound‐healing and analgesic properties of visible and near IR light can be drawn.
In the present work, using polychromatic visible light, close to this dominant component of the terrestrial solar radiation (380–750 nm, ) we irradiated tumor cells of the murine hepatoma (MH‐22a line) under conditions in vitro (the monolayer of cells in Petri dishes) and in vivo (after subcutaneous implantation of these cells to mice of the C3HA line).
A high resistance of the MH‐22a cells to polychromatic visible radiation has been established under conditions in vitro: irradiation at dose did not inhibit their proliferation whereas a dose of stimulated statistically significantly proliferation of the cells (by 24–40%). However, stimulation of the tumor cell proliferation, did not develop under conditions in vivo, when mice were irradiated —daily for 5 days before the implantation of tumor cells and for 5 days after implantation (in the latter case there was a probability of transcutaneous irradiation of tumor cells). By implanting to the animals of tumor cells at various concentrations (from to cells per mouse), we did not revealed at any of 10 terms of observations for 41–45 days both an increase of incidence of the tumor development and acceleration of tumor growth as well as a decrease of the animals survival as compared with group of non‐irradiated animals. Moreover, there was recorded a decrease of incidence of the tumor development—by 16–24%, downregulation of the tumor growth rate—on average, by 40% and an increase of survival of the animals (by 20%). Thus, for the first time, an antitumor effect of polychromatic visible light has been shown at its application on the body surface of experimental animals.
- Cell growth
- Visible light
- Infrared radiation effects
- Solar effects
- Solar radiation
- Comparative animal models
- Infrared radiation
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