- Conference date: 17–21 May 2009
- Location: Cairo (Egypt)
Fluorescence spectroscopy is an evolving technology that can rapidly differentiate between benign and malignant tissues. These differences are thought to be due to endogenous fluorophores, including nicotinamide adenine dinucleotide, flavin adenine dinucleotide, and tryptophan, and absorbers such as β‐carotene and hemoglobin. This is a non‐invasive diagnostic tool that can identify diseased tissue sites in situ and in real time could have a major impact on the detection and treatment of cancer. This study evaluates the utility of autofluorescence and spectroscopy to distinguish tissue transformation associated with the malignant change in two types of human cancer—colorectal and breast cancer—Fluorescence spectra were obtained using a high‐sensitivity fiber optic spectrometer and using two types of excitation sources, Argon laser with an emission at wavelength 488 nm and Xenon lamp. The results showed that the fluorescence intensity changes from normal to malignant tissue samples may be explained in terms of simple collagen, oxidized riboflavins and NAD(P)H intensity changes. In the future, improving our understanding of the biological changes that can be assessed using spectroscopy will not only improve optical techniques but also provide new tools to better understand cancer biology.
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