Numerical Simulation of Bioparticle Manipulation Using Dielectrophoresis
- Conference date: 27–28 November 2010
- Location: Timisoara (Romania)
The manipulation of biological particles (cells, viruses DNA, proteins) is an important research subject in microfluidics. The dielectrophoresis (DEP) based on AC electrokinetics became one of the most widely used tools in particle separation, due to the low operating voltage (1–20 V), which significantly diminishes the Joule heating of the suspension. The present paper presents a 2‐D model for the DEP‐based separation microsystem consisting of a microchannel controlled with an interdigitated electrode array. The dielectrophoretic force produced by the nonuniform electric field acts on the bioparticles in suspension in fluid medium inducing spatial movement. The force depends on a number of parameters such as the geometry of the electrodes, the frequency of the applied electric field, as well as dielectric properties of the particles and the surrounding medium. The behavior of this type of system is numerically investigated. The electrical field distribution, the DEP force and the concentration profile in the microchannel are computed using a code based on the finite element technique. The analysis of the role of different problem parameters confirms the potential applications of DEP in handling and separation of particles.
- Biological electrophoresis
- Electric fields
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