- Conference date: 9–11 December 2009
- Location: Guwahati, Assam (India)
Cholesterol is one of the most abundant and well known steroids in the animal kingdom. Cholesterol rich micro‐emulsions and nano‐emulsions are useful for the treatment of breast cancer and gynecologic cancers. The nano particles of cholesterol and other pharmaceutically important materials have been reported. In the present investigation, the nano particles of cholesterol were synthesized by direct precipitation technique using triton X‐100/water/n‐butanol micro‐emulsion. The average particle size of cholesterol nano particles was estimated by applying Scherrer’s formula to the powder X‐ray diffraction pattern, which was found to be 22 nm. The nanoparticles of cholesterol were observed by using TEM and the particle size was found within the range from 15 nm–31 nm. The distribution of particle size was studied through DLS. The nanoparticles of cholesterol were characterized by using FT‐IR spectroscopy and the force constant was also calculated for O‐H, C‐H and C‐O bonds. The thermal response of nanoparticles of cholesterol was studied by TGA, which showed that the nanoparticles were stable up to 200 °C and then decomposed. Kinetic and thermodynamic parameters of decomposition process were also calculated by applying Coats and Redfern formula to thermo‐gram.
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