Evaluating Photodynamic Therapy Efficacy Using Laser Induced Breakdown Spectroscopy
- Conference date: 1–5 May 2011
- Location: Cairo, (Egypt)
Laser‐induced breakdown spectroscopy (LIBS), is an excellent tool for trace elemental analysis, was exploited for a detecting concentrations of calcium and magnesium in malignant tissues before and after PDT. Calcium and magnesium concentrations are known tobe high in malignancy. Tissues were injected with methylene blue photosensitizer with concentrations 0.5%, 1% and 2%. Two different light sources were used with two different energy densities/each light sources. The results showed a decrease in tissue elements content after PDT application for both calcium and magnesium compared to before PDT application as shown in the tissue spectral lines’ intensities which has been reflected in. Type of light source showed no effect on tissue elements content which showed slight differences among the different energy densities. It has been shown that LIBS technique can be adopted method to monitor tumor photodynamic therapy applications.
- Photodynamic therapy
- Laser induced breakdown spectroscopy
- Energy content
- Laser induced breakdown
- Spectrum analysis
- Visible spectra
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