- Conference date: 3−4 NOV 1987
- Location: SANIBEL ISLAND, FLORIDA (USA)
Almost 25 years ago a large group of Rhesus monkeys were irradiated with protons (32–2300 MeV). The experiments were designed: 1) To estimate the RBE of protons, per se, and 2) To provide some estimate of the hazards of the radiation environment of space. The initial results showed the RBE to be about 1.0 for acute radiation effects (mortality, hematologic changes, etc). The colony has been maintained at Brooks AFB, TX since irradiation. The survivors of 55 MeV proton irradiation have developed a very high incidence of Glioblastoma multiforme, a highly malignant primary brain tumor. These tumors appeared 1–20 yrs after surface doses of 400–800 rads. Reconstruction of the dosimetry suggests that some areas within the brain may have received doses of 1500–2500 rads. More than 30 radiation induced Glioblastomas have been reported in human patients who had received therapeutic head irradiation. The radiation doses required to induce Glioblastoma were of the same order of magnitude as required to induce Glioblastoma in the Rhesus monkey.
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