Ablation produced using a toroidal high intensity focused ultrasound device is independent of hepatic perfusion
- Conference date: 11–13 April 2011
- Location: New York, NY, USA
In this study an ultrasound device that uses a toroidal HIFU transducer guided by ultrasound imaging was evaluated clinically for the treatment of colorectal liver metastases during an open procedure. Our long-term objective is to associate HIFU with hepatic resection. Here we report the first clinical results obtained on six patients with liver metastases and scheduled for elective surgical resection of their tumors. The principal objective was to validate the effectiveness, tolerance and safety of the HIFU parameters defined during preclinical studies. In addition, the response to HIFU was assessed using the ultrasound imaging probe integrated in the HIFU device and compared directly with histological analysis. Twelve HIFU lesions were performed during hepatectomy. The dimensions measured on ultrasound imaging were correlated (r=0.91) with dimensions measured during histological analysis. The average coagulated dimensions obtained from a single 40s exposure were a diameter of 18.7±2.0 mm and a depth of 27.5±6.3 mm. This HIFU treatment using a toroidal transducer is feasible, safe and well tolerated. This device is capable of achieving selective ablation of predefined liver regions. Ultrasound imaging evidence of complete ablation of the target region can be taken to infer histological success.
- Image analysis
- Ultrasonic transducers
- Safety procedures
MOST READ THIS MONTH
MOST CITED THIS MONTH
Y. K. Semertzidis, M. Aoki, M. Auzinsh, V. Balakin, A. Bazhan, G. W. Bennett, R. M. Carey, P. Cushman, P. T. Debevec, A. Dudnikov, F. J. M. Farley, D. W. Hertzog, M. Iwasaki, K. Jungmann, D. Kawall, B. Khazin, I. B. Khriplovich, B. Kirk, Y. Kuno, D. M. Lazarus, L. B. Leipuner, V. Logashenko, K. R. Lynch, W. J. Marciano, R. McNabb, W. Meng, J. P. Miller, W. M. Morse, C. J. G. Onderwater, Y. F. Orlov, C. S. Ozben, R. Prigl, S. Rescia, B. L. Roberts, N. Shafer‐Ray, A. Silenko, E. J. Stephenson, K. Yoshimura and EDM Collaboration
Article metrics loading...