- Conference date: 10–13 June 2012
- Location: Heidelberg, Germany
Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused ultrasound). In this work, the effects of treatment parameters on HIFU thermal lesion volume and temperature are investigated. Ex vivo tissues were treated with a 2 MHz HIFU beam in absence and presence of the Artenga® microbubbles at varying HIFU focal intensities (600-2400 W/cm2), microbubble concentrations, and exposure durations (3-10 s). The temperature was measured at 1 mm from the focus using a K-type calibrated thermocouple. Thermal lesion volume was measured based on an ellipsoid model. Microbubbles increased the lesion volume and peak temperature achieved with HIFU. At the intensity of 2316 W/cm2, the lesion volume increased by two folds, and the peak temperature increased by 16 °C with microbubbles. This effect depended on microbubble concentration, ultrasound intensity and exposure duration. Lower intensities and shorter exposure time durations were required at higher microbubble concentrations to ablate the tissue. It was concluded that the efficacy of the HIFU therapy in combination with microbubbles can be controlled through ultrasound and microbubble exposure parameters.
- Fluid bubbles
- Ultrasonic effects
- Temperature measurement
Daniel Baumann, Mark G. Jackson, Peter Adshead, Alexandre Amblard, Amjad Ashoorioon, Nicola Bartolo, Rachel Bean, Maria Beltrán, Francesco de Bernardis, Simeon Bird, Xingang Chen, Daniel J. H. Chung, Loris Colombo, Asantha Cooray, Paolo Creminelli, Scott Dodelson, Joanna Dunkley, Cora Dvorkin, Richard Easther, Fabio Finelli, Raphael Flauger, Mark P. Hertzberg, Katherine Jones‐Smith, Shamit Kachru, Kenji Kadota, Justin Khoury, William H. Kinney, Eiichiro Komatsu, Lawrence M. Krauss, Julien Lesgourgues, Andrew Liddle, Michele Liguori, Eugene Lim, Andrei Linde, Sabino Matarrese, Harsh Mathur, Liam McAllister, Alessandro Melchiorri, Alberto Nicolis, Luca Pagano, Hiranya V. Peiris, Marco Peloso, Levon Pogosian, Elena Pierpaoli, Antonio Riotto, Uroš Seljak, Leonardo Senatore, Sarah Shandera, Eva Silverstein, Tristan Smith, Pascal Vaudrevange, Licia Verde, Ben Wandelt, David Wands, Scott Watson, Mark Wyman, Amit Yadav, Wessel Valkenburg and Matias Zaldarriaga
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