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Volume 126, Issue 4, October 2009
- ULTRASONICS, QUANTUM ACOUSTICS, AND PHYSICAL EFFECTS OF SOUND 
Wave scattering from encapsulated microbubbles subject to high-frequency ultrasound: Contribution of higher-order scattering modes126(2009); http://dx.doi.org/10.1121/1.3203917View Description Hide Description
The theoretical understanding of encapsulated microbubble response to high-frequency ultrasound (HFUS) excitation is still limited although some novel experimental HFUS contrast imaging techniques have been well developed. In this paper, the higher-order modal (HOM) contributions to the scattered field are studied for such microbubbles driven by 1–100 MHz ultrasound. An exact solution of all small-amplitude vibrational modes of a single encapsulated microbubble in water is given by the wave scattering theory (WST) method and compared to results obtained from Church’s Rayleigh–Plesset-like model for the small-amplitude radial oscillation of a microbubble in an incompressible fluid. From numerical results, we show that the HOM field contribution is significant for scattering properties from individual Nycomed microbubbles with normalized frequency . It is also shown that the multiple scattering is strengthened for monodispersed Definity®microbubbles of radius at frequencies . However, comparisons between the authors' analyses and known experimental data for polydispersed Definity®microbubbles indicate that the HOM contributions are insignificant in attenuation estimation at frequencies . In conclusion, the WST model analysis suggests that HOM scattering is an important consideration for single bubbles but may be less critical in the modeling of polydispersed Definity®bubbles at high frequencies.