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Ambient pressure sensitivity of microbubbles investigated through a parameter study
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10.1121/1.3242359
/content/asa/journal/jasa/126/6/10.1121/1.3242359
http://aip.metastore.ingenta.com/content/asa/journal/jasa/126/6/10.1121/1.3242359

Figures

Image of FIG. 1.
FIG. 1.

(a) shows the energy of the subharmonic component as a function of emitted frequency, while (b) shows the relation of the subharmonic to the fundamental component.

Image of FIG. 2.
FIG. 2.

Energy as a function of acoustic pressure for Sonazoid. The driving pulse is a rectangular shaped sinusoid. Upper left graph shows the subharmonic behavior, upper right shows the first harmonic, and lower left presents the behavior of the second harmonic component. Each curve represents a different number of cycles in the driving pulse, as displayed in the legend to the lower right in the figure.

Image of FIG. 3.
FIG. 3.

Energy as a function of acoustic pressure for Sonazoid. The driving pulse is a Hanning shaped sinusoid. Upper left graph shows the subharmonic behavior, upper right shows the first harmonic, and lower left presents the behavior of the second harmonic component. Each curve represents a different number of cycles in the driving pulse, as displayed in the legend to the lower right in the figure.

Image of FIG. 4.
FIG. 4.

Energy as a function of acoustic pressure for Levovist. The driving pulse is a rectangular shaped (a) and a Hanning shaped (b) sinusoid, respectively. Upper left graph shows the subharmonic behavior, upper right shows the first harmonic, and lower left presents the behavior of the second harmonic component. Each curve represents a different number of cycles in the driving pulse, as displayed in the legend to the lower right in the figure.

Image of FIG. 5.
FIG. 5.

Example of scattered pressure (a) and its corresponding spectrum (b) when using a Hanning shaped driving pulse. Sonazoid is used and the excitation is a 20 cycle Hanning shaped signal with a center frequency of 2 MHz and an acoustic pressure of 525 kPa.

Image of FIG. 6.
FIG. 6.

Example of spectrum of scattered response from excitation of microbubble corresponding to Levovist. The driving pulse is a 32 cycle rectangular shaped signal with a center frequency of and an acoustic pressure of . (a) is when no overpressure is applied and (b) shows the response when an overpressure of 25 kPa is applied.

Image of FIG. 7.
FIG. 7.

Energy of the subharmonic component scattered by Levovist when using a rectangular shaped driving pulse with an acoustic pressure of 800 kPa. The energy is displayed as a function of ambient pressure, and each curve in the plot represents a different number of cycles in the driving pulse, as indicated by the legend.

Image of FIG. 8.
FIG. 8.

Decrease in energy of respective frequency components scattered by Levovist when using a rectangular shaped driving pulse with an acoustic pressure of 800 kPa. The energy is displayed as a function of ambient pressure, and each curve in the plots represents a different number of cycles in the driving pulse, as indicated by the legend.

Image of FIG. 9.
FIG. 9.

Ambient pressure sensitivity of the subharmonic component for Levovist when the ambient pressure is increased from 0 to 25 kPa. The sensitivity is shown as a function of acoustic pressure and number of cycles in the rectangular driving pressure. To the right, the respective correlation coefficients, when using a linear regression model, are shown.

Image of FIG. 10.
FIG. 10.

Ambient pressure sensitivity of the subharmonic component for Sonazoid when the ambient pressure is increased from 0 to 25 kPa. It is shown as a function of acoustic pressure and number of cycles in the rectangular driving pressure.

Tables

Generic image for table
TABLE I.

List of simulation parameters regarding the general setup of BUBBLESIM.

Generic image for table
TABLE II.

List of the parameters from Yu et al. (Ref. 29) and Hoff (Ref. 24) used to describe the two different types of bubbles for the simulations in BUBBLESIM.

Generic image for table
TABLE III.

List of parameters used in combination with the contrast agents listed in Table II. Combining all settings gives 3600 simulations in total for each agent.

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/content/asa/journal/jasa/126/6/10.1121/1.3242359
2009-12-14
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Ambient pressure sensitivity of microbubbles investigated through a parameter study
http://aip.metastore.ingenta.com/content/asa/journal/jasa/126/6/10.1121/1.3242359
10.1121/1.3242359
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