Flow chart diagram demonstrating the method to generate the spatial distribution of red blood cells in clusters that mimic an aggregated blood tissue sample.
(Color online) (a): An arrangement of randomly located red blood cells (represented by circles) for a hematocrit of H = 0.40. (b) A representative plot of a PA signal in arbitrary units (A.U.). (c) Signal envelope histogram (250 RF lines were used). (d) Plots of PA power spectra for blood samples at different hematocrits. (e) Same as (d) but plotted on a log–log scale. (f) Variation of mean (±1 SD) of the PA signal amplitudes with hematocrit.
(Color online) (a): An arrangement of randomly located RBC clusters for H = 0.40. Small circles are individual RBCs and big circles show the cluster boundaries (with mean radius of gyration, Rg = 12.24 ). (b) A representative plot of a PA signal. (c) Signal envelope histogram (250 RF lines were used). (d) Plots of PA power spectra starting from non-aggregated blood sample with Rg = 2.13 to other samples with different cluster sizes but at fixed hematocrit of 40%. Cluster size increased as Rg increased. (e) Same as (d) but plotted on a log–log scale. In this figure the same sequence of (d) has been used to draw the curves associated with different aggregation levels. (f) Variation of mean PA signal amplitude with mean RBC cluster size (expressed in radius of gyration, Rg ).
Physical constants and parameters used in simulations.
RBC aggregation parameters associated with various simulated tissue samples.
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