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Temperature dependent ultrasonic characterization of biological media
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10.1121/1.3626162
/content/asa/journal/jasa/130/4/10.1121/1.3626162
http://aip.metastore.ingenta.com/content/asa/journal/jasa/130/4/10.1121/1.3626162

Figures

Image of FIG. 1.
FIG. 1.

(Color online) Histopathology images of 4T1 biophantom at (a) 37 °C (b) 40 °C (c) 45 °C (d) 50 °C (e) 37 °C and (f) CHO biophantom at 37 °C. The scale bar in (a), (b), (c) and (d) is 50 μm, and in panels (e) and (f) is 200 μm.

Image of FIG. 2.
FIG. 2.

Experimental setup.

Image of FIG. 3.
FIG. 3.

(Color online) Temperature profile of the biophantom after the mixture of cells and agar were poured into the six well plate until the start of the ultrasound experiment and the corresponding thermal dose.

Image of FIG. 4.
FIG. 4.

Estimated sound speed from (a) CHO biophantom (b) 4T1 biophantom, (c) rabbit liver and (d) beef liver samples versus temperature from 37 °C to 50 °C.

Image of FIG. 5.
FIG. 5.

Estimated attenuation from (a) CHO biophantom (b) 4T1 biophantom, (c) rabbit liver and (d) beef liver samples versus temperature from 37 °C to 50 °C.

Image of FIG. 6.
FIG. 6.

Backscatter coefficient at different temperatures for (a) CHO biophantom, (b) 4T1 biophantom and (c) rabbit liver sample (d) beef liver samples (the legend bar is in °C).

Image of FIG. 7.
FIG. 7.

Comparison of backscatter coefficient and Gaussian model.

Image of FIG. 8.
FIG. 8.

Changes in ESD and EAC with increasing temperature and mean thermal dose (a) ΔESD for CHO, (b) ΔEAC for CHO, (c) ΔESD for 4T1, and (d) ΔEAC for 4T1.

Image of FIG. 9.
FIG. 9.

Changes in ESD and EAC with increasing temperature and mean thermal dose (a) ΔESD for beef liver, (b) ΔEAC for beef liver, (c) ΔESD for rabbit liver, and (d) ΔEAC for rabbit liver samples.

Image of FIG. 10.
FIG. 10.

The mean and the variance of EAC estimates with increasing temperature for biophantoms and liver samples.

Tables

Generic image for table
TABLE I.

Changes in ESD and EAC at constant temperature of 37 °C and for variable temperature case.

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/content/asa/journal/jasa/130/4/10.1121/1.3626162
2011-10-03
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Temperature dependent ultrasonic characterization of biological media
http://aip.metastore.ingenta.com/content/asa/journal/jasa/130/4/10.1121/1.3626162
10.1121/1.3626162
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