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Surfactant shedding and gas diffusion during pulsed ultrasound through a microbubble contrast agent suspension
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10.1121/1.4812860
/content/asa/journal/jasa/134/2/10.1121/1.4812860
http://aip.metastore.ingenta.com/content/asa/journal/jasa/134/2/10.1121/1.4812860

Figures

Image of FIG. 1.
FIG. 1.

Size distribution for SonoVue microbubbles used in the simulations. Measurements were obtained from optical micrographs (Ref. ). Frequency refers to the number of bubbles counted in each size range. The mean radius, determined from approximately 200 bubbles, was approximately 1.4 m.

Image of FIG. 2.
FIG. 2.

Changes in the SonoVue size distribution after insonation by six 2.25 MHz pulses for different pressure amplitudes at a concentration of 10 bubbles per m. The mean radius after the sixth pulse is (a) 1.4 m, (b) 1.2 m, (c) 1.1 m, (d) 0.9 m.

Image of FIG. 3.
FIG. 3.

Changes in the SonoVue size distribution after insonation by six 1 MHz pulses for different pressure amplitudes at a concentration of 10 bubbles per m. The mean radius after the sixth pulse is (a) 1.4 m, (b) 1.1 m, (c) 0.9 m, and (d) 0.6 m.

Image of FIG. 4.
FIG. 4.

Changes in the SonoVue size distribution after insonation by six 4 MHz pulses for different pressure amplitudes at a concentration of 10 bubbles per m. The mean radius after the sixth pulse is (a) 1.4 m, (b) 1.4 m, (c) 1.3 m, and (d) 1.2 m.

Image of FIG. 5.
FIG. 5.

Proportion of surfactant remaining on the microbubbles over six pulses for different center frequencies and peak negative pressures.

Image of FIG. 6.
FIG. 6.

The calculated attenuation of the fundamental and amplitude of the second harmonic component of the signal for six 2.25 MHz pulses propagating 2 cm through a SonoVue population distribution of concentration 10 bubbles per m.

Image of FIG. 7.
FIG. 7.

The calculated attenuation of the fundamental and amplitude of the second harmonic component of the signal for six 1 MHz pulses propagating 2 cm through a SonoVue population distribution of concentration 10 bubbles per m.

Image of FIG. 8.
FIG. 8.

The calculated attenuation of the fundamental and amplitude of the second harmonic component of the signal for six 4 MHz pulses propagating 2 cm through a SonoVue population distribution of concentration 10 bubbles per m.

Image of FIG. 9.
FIG. 9.

The changes in the SonoVue size distribution after insonation by six 2.25 MHz pulses for different pressures at a concentration of 10 bubbles per m using a constant surface tension . The mean radius after the sixth pulse is (a) 1.4 m, (b) 1.3 m, (c) 1.2 m, and (d) 1.1 m.

Image of FIG. 10.
FIG. 10.

The calculated attenuation of the fundamental and amplitude of the second harmonic component of the signal for six 2.25 MHz pulses propagating 2 cm through a SonoVue® population distribution of concentration 10 bubbles per m, using a constant surface tension in the bubble equation of motion.

Tables

Generic image for table
TABLE I.

Parameter values adopted for numerical simulations.

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/content/asa/journal/jasa/134/2/10.1121/1.4812860
2013-08-01
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Surfactant shedding and gas diffusion during pulsed ultrasound through a microbubble contrast agent suspension
http://aip.metastore.ingenta.com/content/asa/journal/jasa/134/2/10.1121/1.4812860
10.1121/1.4812860
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