Volume 135, Issue 2, February 2014
Index of content:
- ULTRASONICS, QUANTUM ACOUSTICS, AND PHYSICAL EFFECTS OF SOUND 
Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound135(2014); http://dx.doi.org/10.1121/1.4843175View Description Hide Description
Ultrasound contrast agents (UCAs) can be employed to nucleate cavitation to achieve desired bioeffects, such as thrombolysis, in therapeutic ultrasound applications. Effective methods of enhancing thrombolysis with ultrasound have been examined at low frequencies (<1 MHz) and low amplitudes (<0.5 MPa). The objective of this study was to determine cavitation thresholds for two UCAs exposed to 120-kHz ultrasound. A commercial ultrasound contrast agent (Definity®) and echogenic liposomes were investigated to determine the acoustic pressure threshold for ultraharmonic (UH) and broadband (BB) generation using an in vitro flow model perfused with human plasma. Cavitation emissions were detected using two passive receivers over a narrow frequency bandwidth (540–900 kHz) and a broad frequency bandwidth (0.54–1.74 MHz). UH and BB cavitation thresholds occurred at the same acoustic pressure (0.3 ± 0.1 MPa, peak to peak) and were found to depend on the sensitivity of the cavitation detector but not on the nucleating contrast agent or ultrasound duty cycle.
135(2014); http://dx.doi.org/10.1121/1.4861360View Description Hide Description
The dynamic stability of Rayleigh-Bénard convection with vertical vibration in a cubic container is computationally modeled. Two parametric drives are considered (sinusoidal and rectangular), as well as two thermal boundary conditions on the sidewalls (insulating and conducting). The linearized equations are solved using a spectral Galerkin method and Floquet analysis. Both the synchronous and the subharmonic regions of instability are recovered. The conditions necessary for dynamic stability are reported for a range of Rayleigh numbers from critical to 107 and for Prandtl numbers in the range of 0.1–7. The linear model is compared to the data set available in the literature where the performance of an inverted pulse tube cryocooler is measured.