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/content/asa/journal/jasa/137/5/10.1121/1.4916790
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/content/asa/journal/jasa/137/5/10.1121/1.4916790
2015-05-06
2016-09-30

Abstract

assessment of microscale tissue biomechanical properties of the mammalian retina could offer insights into diseases such as keratoconus, and macular degeneration. A 250-MHz scanning acoustic microscope (7-m resolution) has been constructed to derive two-dimensional quantitative maps of attenuation (), speed of sound (), acoustic impedance (), bulk modulus (), and mass density ( ). The two-dimensional maps were compared to coregistered hematoxylin-and-eosin stained sections. This study is the first to quantitatively assess , and of individual retinal layers of mammalian animals at high ultrasound frequencies. Significant differences in these parameters between the layers were demonstrated.

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