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1. Bao, S. , Thrall, B. D. , and Miller, D. L. (1997). “ Transfection of a reporter plasmid into cultured cells by sonoporation in vitro,” Ultrasound Med. Biol. 23, 953959.
2. Culp, W. C. , Flores, R. , Brown, A. T. , Lowery, J. D. , Roberson, P. K. , Hennings, L. J. , Woods, S. D. , Hatton, J. H. , Culp, B. C. , Skinner, R. D. , and Borelli, M. J. (2011). “ Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke,” Stroke 42, 22802285.
3. Czarnota, C. J. , Karshafian, R. , Burns, P. N. , Wong, S. , Mahrouki, A. A. , Lee, J. W. , Caissie, A. , Tran, W. , Kim, C. , Furukawa, M. , Wong, E. , and Giles, A. (2012). “ Tumor radiation response enhancement by acoustical stimulation of the vasculature,” Proc. Natl. Acad. Sci. U.S.A. 109, E2033E2041.
4. Karshafian, R. , Almasri, F. , Giles, A. , and Czarnota, G. J. (2010). “ Enhancing chemotherapy by ultrasound and MBs: Effect of acoustic pressure and treatment order in in vitro suspension of breast and prostate cancer cells,” in Proceedings of the 2010 IEEE International Ultrasonics Symposium, San Diego, CA, pp. 15821585.
5. Karshafian, R. , Giles, A. , Burns, P. N. , and Czarnota, G. J. (2009). “ Ultrasound stimulated microbubbles as novel enhancers of radiotherapy in Leukemia cells in vitro,” in Proceedings of the 2009 IEEE International Ultrasonics Symposium, Rome, Italy, pp. 17921795.
6. King, D. A. , and O'Brien, W. D. , Jr. (2014). “ Quantitative analysis of ultrasound contrast agent postexcitation collapse,” IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 61, 12371241.
7. McDannold, N. J. , Vykhodsteva, N. I. , and Hynynen, K. (2006). “ Microbubble contrast agent with focused ultrasound to create brain lesions at low power: MR imaging and histologic study in rabbits,” Radiology 241, 95106.
8. Moyer, H. R. , and Delman, K. A. (2008). “ The role of hyperthermia in optimizing tumor response to regional therapy,” Int. J. Hyperthermia 24, 251261.
9. Perez, C. A. , and Sapareto, S. A. (1984). “ Thermal dose expression in clinical hyperthermia and correlation with tumor response/control,” Cancer Res. 44, 48184825.
10. Sapareto, S. A. , and Dewey, W. C. (1984). “ Thermal dose determination in cancer therapy,” Int. J. Radiation Oncol. Biol. Phys. 10, 787800.
11. ter Haar, G. , Stratford, I. J. , and Hill, C. R. (1980). “ Ultrasonic irradiation of mammalian cells in vitro at hyperthermic temperatures,” Br. J. Radiol. 53, 784789.
12. Tran, W. T. , Iradji, S. , Sofroni, E. , Giles, A. , Eddy, D. , and Czarnota, G. J. (2012). “ Microbubble and ultrasound radioenhancement of bladder cancer,” Br. J. Cancer 107, 469476.
13. van de Loosdrecht, A. A. , Beelen, R. H. J. , Ossenkoppele, G. J. , Broekhoven, M. G. , and Langenhuijsen, M. M. A. C. (1994). “ A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukimc cells from cell lines and patient with acute myeloid leukemia,” J. Immunol. Methods 174, 311320.
14. van der Zee, T. (2002). “ Heating the patient: A promising approach?,” Ann. Oncol. 13, 11731184.

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Ultrasound-stimulated microbubbles (MBs) were demonstrated to enhance cell kill from hyperthermia. Definity MBs were injected into wells containing 4T1 cells in culture media and scanned with 1-MHz ultrasound, an exposure duration of 30 s and a negative pressure of 0.5 or 1.3 MPa. Some cell samples were placed in a water bath heated to 42 °C for 5 min. Cell death was quantified. When combining MBs, ultrasound at 1.3 MPa and hyperthermia, more than 58.8% ± 7.21% of cells were nonviable. When exposed to hyperthermia alone or exposure to MBs and ultrasound but no hyperthermia, cell death was less than 10.1% ± 6.96% and 30.1% ± 10.8%, respectively.


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