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The microscale evolution of the erosion front of blood clots exposed to ultrasound stimulated microbubbles
2. B. Petit, Y. Bohren, E. Gaud, P. Bussat, M. Arditi, F. Yan, and F. Tranquart, “ Sonothrombolysis: The contribution of stable and inertial cavitation to clot lysis,” Ultrasound Med. Biol. 41, 1402–1410 (2015).
3. S. Datta, C. C. Coussios, A. Y. Ammi, T. D. Mast, G. M. De Courten-Myers, and C. K. Holland, “ Ultrasound-enhanced thrombolysis using definity as a cavitation nucleation agent,” Ultrasound Med. Biol. 34, 1421–1433 (2008).
4. F. Xie, E. C. Everbach, S. Gao, L. K. Drvol, W. T. Shi, F. Vignon, J. E. Powers, J. Lof, and T. R. Porter, “ Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution.,” Ultrasound Med. Biol. 37, 280–288 (2011).
5. C. Acconcia, B. Y. C. Leung, K. Hynynen, and D. E. Goertz, “ Interactions between ultrasound stimulated microbubbles and fibrin clots,” Appl. Phys. Lett. 103, 053701 (2013).
7. M. E. Carr and C. L. Hardin, “ Fibrin has larger pores when formed in the presence of erythrocytes,” Am. J. Physiol. 253, H1069–H1073 (1987).
8. K. C. Gersh, C. Nagaswami, and J. W. Weisel, “ Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes,” Thromb. Haemost. 102, 1169–1175 (2009).
9. P. Aarts, P. Bolhuis, K. Sakariassen, R. Heethaar, and J. Sixma, “ Red blood cell size is important for adherence of blood platelets to artery subendothelium,” Blood 62, 214–217 (1983).
10. B. Arslan, U. C. Turba, and A. H. Matsumoto, “ Acute renal failure associated with percutaneous mechanical thrombectomy for iliocaval venous thrombosis,” Semin. Interv. Radiol. 24, 288–295 (2007).
11. B. L. Helfield, B. Y. C. Leung, and D. E. Goertz, “ The effect of boundary proximity on the response of individual ultrasound contrast agent microbubbles,” Phys. Med. Biol. 59, 1721–1745 (2014).
14. I. Bucay, T. E. O'Brien III, S. D. Wulfe, R. Superfine, A. S. Wolberg, M. R. Falvo, and N. E. Hudson, “ Physical determinants of fibrinolysis in single fibrin fibers,” PLoS One 10, e0116350 (2015).
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Serial two-photonmicroscopy of blood clots with fluorescently tagged fibrin networks was conducted during microbubble-mediated sonothrombolysis to examine the microscale evolution of the resulting erosion front. The development of a complex zonal erosion pattern was observed, comprised of a cell depleted layer of fibrin network overlying intact clot which then underwent progressive recession. The fibrin zone architecture was dependent on exposure conditions with 0.1 MPa causing no erosion, 0.39 MPa resulting in homogenous structure, and combination 0.39/0.96 MPa pulses forming large-scale tunnels. High speed imaging and Coulter counter data indicated the fibrin zone formation process involves the ejection of intact erythrocytes.
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