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1.
R. Gramiak and P. Shah, “ Echocardiography of the aortic root,” Invest. Radiol. 3, 356366 (1968).
http://dx.doi.org/10.1097/00004424-196809000-00011
2.
S. Sirsi and M. Borden, “ Microbubble compositions, properties, and biomedical applications,” Bubble Sci. Eng. Technol. 1, 317 (2009).
http://dx.doi.org/10.1179/175889709X446507
3.
B. P. Davidson and J. R. Lindner, “ Future applications of contrast echocardiography,” Heart 98, 246253 (2012).
http://dx.doi.org/10.1136/heartjnl-2011-300737
4.
S. R. Wilson and P. N. Burns, “ Microbubble-enhanced US in body imaging: What role?” Radiology 257, 2439 (2010).
http://dx.doi.org/10.1148/radiol.10091210
5.
A. Novell, J. M. Escoffre, and A. Bouakaz, “ Ultrasound contrast imaging in cancer—Technical aspects and prospects,” Curr. Mol. Imag. 2, 7788 (2013).
http://dx.doi.org/10.2174/2211555211302010009
6.
R. X. Xu, S. P. Povoski, and E. W. Martin, Jr., “ Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors,” Expert Rev. Med. Dev. 7, 303306 (2010).
http://dx.doi.org/10.1586/erd.10.9
7.
M. de Saint Victor, C. Crake, C. C. Coussios, and E. Stride, “ Properties, characteristics and applications of microbubbles for sonothrombolysis,” Exp. Opin. Drug Deliv. 11, 187209 (2014).
http://dx.doi.org/10.1517/17425247.2014.868434
8.
J. M. Escoffre, A. Zeghimi, A. Novell, and A. Bouakaz, “ In-vivo gene delivery by sonoporation: Recent progress and prospects,” Curr. Gene Theory 13, 214 (2012).
http://dx.doi.org/10.2174/1566523211313010002
9.
J. E. Chomas, P. Dayton, J. Allen, K. Morgan, and K. W. Ferrara, “ Mechanisms of contrast agent destruction,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 48, 232248 (2001).
http://dx.doi.org/10.1109/58.896136
10.
O. Couture, P. D. Bevan, E. Cherin, K. Cheung, P. N. Burns, and F. S. Foster, “ Investigating perfluorohexane particles with high-frequency ultrasound,” Ultrasound Med. Biol. 32, 7382 (2006).
http://dx.doi.org/10.1016/j.ultrasmedbio.2005.09.010
11.
A. H. Lo, O. D. Kripfgans, P. L. Carson, E. D. Rothman, and J. B. Fowlkes, “ Acoustic droplet vaporization threshold: Effects of pulse duration and contrast agent,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54, 933946 (2007).
http://dx.doi.org/10.1109/TUFFC.2007.339
12.
P. S. Sheeran, V. P. Wong, S. Luois, R. J. McFarland, W. D. Ross, S. Feingold, T. O. Matsunaga, and P. A. Dayton, “ Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging,” Ultrasound Med. Biol. 37, 15181530 (2011).
http://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.021
13.
N. Reznik, R. Williams, and P. N. Burns, “ Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent,” Ultrasound Med. Biol. 37, 12711279 (2011).
http://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.001
14.
D. Thakkar, R. Gupta, K. Monson, and N. Rapoport, “ Effect of ultrasound on the permeability of vascular wall to nano-emulsion droplets,” Ultrasound Med. Biol. 39, 18041811 (2013).
http://dx.doi.org/10.1016/j.ultrasmedbio.2013.04.008
15.
O. Shpak, M. Verweij, H. J. Vos, N. de Jong, D. Lohse, and M. Versluis, “ Acoustic droplet vaporization is initiated by superharmonic focusing,” Proc. Natl. Acad. Sci. U.S.A. 111, 16971702 (2014).
http://dx.doi.org/10.1073/pnas.1312171111
16.
O. D. Kripfgans, J. B. Fowlkes, D. L. Miller, O. P. Eldevik, and P. L. Carson, “ Acoustic droplet vaporization for therapeutic and diagnostic applications,” Ultrasound Med. Biol. 26, 11771189 (2000).
http://dx.doi.org/10.1016/S0301-5629(00)00262-3
17.
N. Reznik, G. Lajoinie, O. Shpak, E. C. Gelderblom, R. Williams, N. de Jong, M. Versluis, and P. N. Burns, “ On the acoustic properties of vaporized submicron perfluorocarbon droplets,” Ultrasound Med. Biol. 40, 13791384 (2014).
http://dx.doi.org/10.1016/j.ultrasmedbio.2013.11.025
18.
P. S. Sheeran, J. D. Rojas, C. Puett, J. Hjelmquist, C. B. Arena, and P. A. Dayton, “ Contrast-enhanced ultrasound imaging and in vivo circulatory kinetics with low-boiling-point nanoscale phase-change perfluorocarbon agents,” Ultrasound Med. Biol. 41, 814831 (2015).
http://dx.doi.org/10.1016/j.ultrasmedbio.2014.10.020
19.
M. L. Fabiilli, K. J. Haworth, N. H. Fakhri, O. D. Kripfgans, P. L. Carson, and J. B. Fowlkes, “ The role of inertial cavitation in acoustic droplet vaporization,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56, 10061017 (2009).
http://dx.doi.org/10.1109/TUFFC.2009.1132
20.
C. C. Chen, P. S. Sheeran, S. Y. Wu, O. O. Olumolade, P. A. Dayton, and E. E. Konofagou, “ Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets,” J. Control Release 172, 795804 (2013).
http://dx.doi.org/10.1016/j.jconrel.2013.09.025
21.
S. T. Kang, Y. C. Lin, and C. K. Yeh, “ Mechanical bioeffects of acoustic droplet vaporization in vessel-mimicking phantoms,” Ultrason. Sonochem. 21, 18661874 (2014).
http://dx.doi.org/10.1016/j.ultsonch.2014.03.007
22.
P. S. Sheeran, T. O. Matsunaga, and P. A. Dayton, “ Phase change events of volatile liquid perfluorocarbon contrast agents produce unique acoustic signatures,” Phys. Med. Biol. 59, 379401 (2014).
http://dx.doi.org/10.1088/0031-9155/59/2/379
23.
L. C. Phillips, P. S. Sheeran, C. Puett, K. F. Timbie, R. J. Price, G. Wilson Miller, and P. A. Dayton, “ Dual perfluorocarbon nanodroplets enhance high intensity focused ultrasound heating and extend therapeutic window in vivo,” J. Acoust. Soc. Am. 134, 4049 (2013).
http://dx.doi.org/10.1121/1.4830779
24.
C. B. Arena, A. Novell, P. S. Sheeran, C. Puett, L. C. Moyer, and P. A. Dayton, “ Dual-frequency acoustic droplet vaporization detection for medical imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62, 16231633 (2015).
http://dx.doi.org/10.1109/TUFFC.2014.006883
25.
G. Caliano, R. Carotenuto, E. Cianci, V. Foglietti, A. Caronti, A. Iula, and M. Pappalardo, “ Design, fabrication and characterization of a capacitive micromachined ultrasonic probe for medical imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52, 22592269 (2005).
http://dx.doi.org/10.1109/TUFFC.2005.1563268
26.
Y. Huang, E. Haeggstrom, B. Bayram, X. Zhuang, A. S. Ergun, C. H. Cheng, and B. T. Khuri-Yakub, “ Comparison of conventional and collapsed region operation of capacitive micromachined ultrasonic transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 53, 19181933 (2006).
http://dx.doi.org/10.1109/TUFFC.2006.125
27.
S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, Jr., and B. T. Khuri-Yakub, “ Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56, 24112419 (2009).
http://dx.doi.org/10.1109/TUFFc.2009.1329
28.
A. Novell, J. M. Escoffre, and A. Bouakaz, “ Second harmonic and subharmonic for non-linear wideband contrast imaging using a capacitive micromachined ultrasonic transducer array,” Ultrasound Med. Biol. 39, 15001512 (2013).
http://dx.doi.org/10.1016/j.ultrasmedbio.2013.03.002
29.
P. Cristman, O. Oralkan, X. Zhuang, T. J. Ma, S. Vaithilingam, T. Carver, I. O. Wygant, and B. T. Khuri-Yakub, “ A 2D CMUT hydrophone array: Characterization results,” in Proceedings of the IEEE Ultrasonics Symposium, Rome (2009), p. 992995.
30.
X. Jin, O. Oralkan, F. L. Degertekin, and B. T. Khuri-Yakub, “ Characterization of one-dimensional capacitive micromachined ultrasonic immersion transducer arrays,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 48, 750760 (2001).
http://dx.doi.org/10.1109/58.920706
31.
K. R. Nightingale, C. C. Church, G. Harris, K. A. Wear, M. R. Bailey, P. L. Carson, H. Jiang, K. L. Sandstrom, T. L. Szabo, and M. C. Ziskin, “ Conditionally increased acoustic pressures in nonfetal diagnostic ultrasound examinations without contrast agents: A preliminary assessment,” J. Ultrasound Med. 34, 141 (2015).
http://dx.doi.org/10.7863/ultra.34.7.15.13.0001
32.
P. S. Sheeran, S. H. Luois, L. B. Mullin, T. O. Matsunaga, and P. A. Dayton, “ Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons,” Biomaterials 33, 32623269 (2012).
http://dx.doi.org/10.1016/j.biomaterials.2012.01.021
33.
M. A. Borden, D. E. Kruse, C. F. Caskey, S. Zhao, P. A. Dayton, and K. W. Ferrara, “ Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52, 19922002 (2005).
http://dx.doi.org/10.1109/TUFFC.2005.1561668
34.
A. Novell, M. Legros, N. Felix, and A. Bouakaz, “ Exploitation of capacitive micromachined transducers for nonlinear ultrasound imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56, 27332743 (2009).
http://dx.doi.org/10.1109/TUFFC.2009.1364
35.
A. Novell, M. Legros, J. M. Gregoire, P. A. Dayton, and A. Bouakaz, “ Evaluation of bias voltage modulation sequence for nonlinear contrast agent imaging using a capacitive micromachined ultrasonic transducer array,” Phys. Med. Biol. 59, 48794896 (2014).
http://dx.doi.org/10.1088/0031-9155/59/17/4879
36.
S. Zhou, P. Reynolds, and J. Hossack, “ Precompensated excitation waveforms to suppress harmonic generation in MEMS electrostatic transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 51, 15641574 (2004).
http://dx.doi.org/10.1109/TUFFC.2004.1367498
37.
S. Satir and F. L. Degertekin, “ Harmonic reduction in capacitive micromachined ultrasonic transducers by gap feedback linearization,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 59, 5059 (2012).
http://dx.doi.org/10.1109/TUFFC.2012.2155
38.
O. M. Viessmann, R. J. Eckersley, K. Christensen-Jeffries, M. X. Tang, and C. Dunsby, “ Acoustic super-resolution with ultrasound and microbubbles,” Phys. Med. Biol. 58, 64476458 (2013).
http://dx.doi.org/10.1088/0031-9155/58/18/6447
39.
Y. Desailly, O. Couture, M. Fink, and M. Tanter, “ Sono-activated ultrasound localization microscopy,” Appl. Phys. Lett. 103, 174107 (2013).
http://dx.doi.org/10.1063/1.4826597
40.
K. H. Martin, B. D. Lindsey, J. Ma, M. Lee, S. Li, F. S. Foster, X. Jiang, and P. A. Dayton, “ Dual-frequency piezoelectric transducers for contrast enhanced ultrasound imaging,” Sensors (Basel) 14, 2082520842 (2014).
http://dx.doi.org/10.3390/s141120825
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/content/asa/journal/jasa/139/6/10.1121/1.4953580
2016-06-23
2016-12-05

Abstract

An ongoing challenge exists in understanding and optimizing the acoustic droplet vaporization (ADV) process to enhance contrast agent effectiveness for biomedical applications. Acoustic signatures from vaporization events can be identified and differentiated from microbubble or tissue signals based on their frequency content. The present study exploited the wide bandwidth of a 128-element capacitive micromachined ultrasonic transducer (CMUT) array for activation (8 MHz) and real-time imaging (1 MHz) of ADV events from droplets circulating in a tube. Compared to a commercial piezoelectric probe, the CMUT array provides a substantial increase of the contrast-to-noise ratio.

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