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Killing adherent and nonadherent cancer cells with the plasma pencil
5. S. Mohades, N. Barekzi, H. Razavi, and M. Laroussi, Proceedings of the Gaseous Electronics Conference, Raleigh, NC, November 2014.
7. S. Iseki, K. Nakamura, M. Hayashi, H. Tanaka, H. Kondo, H. Kajiyama, H. Kano, F. Kikkawa, and M. Hori, Appl. Phys. Lett. 100, 113702 (2012).
19. M. Laroussi and N. Barekzi, Proceedings of the International Conference on Phenomena in Ionized Gases, Granada, Spain, July 2013.
The application of low temperature plasmas in biology and medicine may lead to a paradigm shift in the way various diseases can be treated without serious side effects. Low temperature plasmas generated in gas mixtures that contain oxygen or air produce several chemically reactive species that have important biological implications when they interact with eukaryotic or prokaryotic cells. Here, a review of the effects of low temperature plasma generated by the plasma pencil on different cancerous
cells is presented. Results indicate that plasma consistently shows a delayed killing effect that is dose dependent. In addition, there is some evidence that apoptosis is one of the pathways that leads to the death of the cells, indicating that plasma initiates cell signaling pathways.
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