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Development of a regeneration-type neural interface: A microtube guide for axon growth of neuronal cells fabricated using focused-ion-beam chemical vapor deposition
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10.1116/1.2359730
/content/avs/journal/jvstb/24/6/10.1116/1.2359730
http://aip.metastore.ingenta.com/content/avs/journal/jvstb/24/6/10.1116/1.2359730
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Figures

Image of FIG. 1.
FIG. 1.

Bundle of DLC microtubes attached to the edge of a glass capillary. These had an inner diameter of about .

Image of FIG. 2.
FIG. 2.

Bifurcated microtube attached to a glass capillary. The inner diameter of the end of the microtube was about .

Image of FIG. 3.
FIG. 3.

Carbon microtube on a porous polycarbonate membrane with pore diameter of . The microtube was about in height and in inner diameter as observed by SEM.

Image of FIG. 4.
FIG. 4.

Schematic of the in vitro test using a glass capillary with a bifurcated microtube. The glass capillary and the microtubes were immersed in a culture medium with of NGF added. PC12 cells were cultured in the capillary.

Image of FIG. 5.
FIG. 5.

Schematic of the in vitro test using polycarbonate membranes with straight microtubes. The membranes and the microtubes were immersed in a culture medium with of NGF added. PC12 cells were cultured on the membranes.

Image of FIG. 6.
FIG. 6.

Axons of PC12 extend on DLC thin film ( fabricated by FIB-CVD) at day 2 (day 0: beginning; day 1: addition of NGF; day 2: optical observation). The sharpness of this image was increased by digital image processing.

Image of FIG. 7.
FIG. 7.

Bifurcated microtube in the medium and PC12 cells in a glass capillary observed by optical microscope: (a) bifurcated microtube; (b) differentiated PC12 cells at the tip of the glass capillary. The neurite was observed, but axon extension was not observed.

Image of FIG. 8.
FIG. 8.

Axon extension on a microtube attached to a polycarbonate membrane. (a) SEM image of the microtube and the axon. (b) Schematic of SEM image in (a). The axon grew from the upper right of (a) to the microtube, extended along the inner surface of the microtube, and then exited from it.

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/content/avs/journal/jvstb/24/6/10.1116/1.2359730
2006-10-31
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Development of a regeneration-type neural interface: A microtube guide for axon growth of neuronal cells fabricated using focused-ion-beam chemical vapor deposition
http://aip.metastore.ingenta.com/content/avs/journal/jvstb/24/6/10.1116/1.2359730
10.1116/1.2359730
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