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Optimizing substrate disorder for bone tissue engineering of mesenchymal stem cells
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10.1116/1.2978407
/content/avs/journal/jvstb/26/6/10.1116/1.2978407
http://aip.metastore.ingenta.com/content/avs/journal/jvstb/26/6/10.1116/1.2978407
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Electron micrographs [(A)–(E)] and corresponding FFTs [(F)–(J)] of the polymer replica substrates used for the cell culture experiments. From (A) to (E), the degree of disorder is increasing. With increasing disorder the long range order disappears as is evident from the FFTs [(F)–(J)] and indicated by the arrow. Scale bar corresponds to .

Image of FIG. 2.
FIG. 2.

Changes in osteogenic gene expressions for stro-1 selected mesenchymal stem cells cultured on different degrees of disorder. Pit diameter and depth were kept constant, whereas the degree of disorder was altered , 60, 90, 120, and in and from the true center of a square. was seen to be optimal.

Image of FIG. 3.
FIG. 3.

Changes in osteogenic gene expressions for stro-1 selected mesenchymal stem cells cultured on substrates with altering pit diameter. Pit depth and disorder were kept constant but the dot diameter was altered providing pits with diameters of 50, 150, 165, and . A diameter of was seen to be optimal.

Image of FIG. 4.
FIG. 4.

Changes in osteogenic gene expressions for stro-1 selected mesenchymal stem cells cultured on different tones of topography. Maintaining optimal disorder and diameter pillars were also fabricated with heights of 35 and . The high pillars were seen to be optimal.

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/content/avs/journal/jvstb/26/6/10.1116/1.2978407
2008-12-01
2014-04-23
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Optimizing substrate disorder for bone tissue engineering of mesenchymal stem cells
http://aip.metastore.ingenta.com/content/avs/journal/jvstb/26/6/10.1116/1.2978407
10.1116/1.2978407
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