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Large-scale detection of recombination in nucleotide sequences

AIP Conf. Proc. -- January 30, 2008 -- Volume 971, pp. 101-104
INTERNATIONAL CONFERENCE ON MATHEMATICAL BIOLOGY 2007: ICMB07; doi:10.1063/1.2883829

Issue Date: 30 January 2008

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Cheong Xin Chan,a Robert G. Beiko,b and Mark A. Ragana
aARC Centre of Excellence in Bioinformatics and Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
bFaculty of Computer Science, Dalhousie University, 6050 University Avenue, Halifax, Nova Scotia, Canada B3H 1W5

Genetic recombination following a genetic transfer event can produce heterogeneous phylogenetic histories within sets of genes that share a common ancestral origin. Delineating recombination events will enhance our understanding in genome evolution. However, the task of detecting recombination is not trivial due to effect of more-recent evolutionary changes that can obscure such event from detection. In this paper, we demonstrate the use of a two-phase strategy for detecting recombination events on a large-scale dataset. ©2008 American Institute of Physics
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KEYWORDS and PACS

Keywords
PACS
  • 82.39.Pj
    Nucleic acids, DNA and RNA bases (chemical kinetics)
  • 87.14.E-
    Proteins
  • 02.50.-r
    Probability theory, stochastic processes, and statistics
  • YEAR: 2008

PUBLICATION DATA

ISSN:
0094-243X (print)  
Publisher:
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