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Mechanical resonant immunospecific biological detector

Appl. Phys. Lett. 77, 450 (2000); doi:10.1063/1.127006

Issue Date: 17 July 2000

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B. Ilic, D. Czaplewski, and H. G. Craighead
School of Applied and Engineering Physics and the Nanobiotechnology Center, Cornell University, Ithaca, New York 14853

P. Neuzil
Institute of Microelectronics, Singapore Science Park II, Singapore 117685

C. Campagnolo and C. Batt
Department of Food Science and the Nanobiotechnology Center, Cornell University, Ithaca, New York 14853
We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Measured resonant frequency shift as a function of the additional cell loading was observed and correlated to the mass of the specifically bound Escherichia coli O157:H7 cells. Deposition and subsequent detection of E. coli cells was achieved under ambient conditions. ©2000 American Institute of Physics.
History: Received 11 February 2000; accepted 24 May 2000
Permalink: http://link.aip.org/link/?APPLAB/77/450/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.80.Mj
    Biological and medical physics Biological techniques and instrumentation; biomedical engineering Micromachining
  • 87.80.Tq
    Biological and medical physics Biological techniques and instrumentation; biomedical engineering Biological signal processing and instrumentation
  • YEAR: 2000

PUBLICATION DATA

ISSN:
0003-6951 (print)   1077-3118 (online)
Publisher:
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