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Holographic optical coherence imaging of tumor spheroids

Appl. Phys. Lett. 83, 575 (2003); doi:10.1063/1.1594830

Issue Date: 21 July 2003

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P. Yu and M. Mustata
Department of Physics, Purdue University, 1396 Physics Building, West Lafayette, Indiana 47907-1396

J. J. Turek
Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1246

P. M. W. French
Department of Physics, Imperial College of Science, Technology and Medicine, London, SW7 2BZ United Kingdom

M. R. Melloch
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907-2035

D. D. Nolte
Department of Physics, Purdue University, 1396 Physics Building, West Lafayette, Indiana 47907-1396
We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video "fly-through." The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth. ©2003 American Institute of Physics.
History: Received 10 February 2003; accepted 13 May 2003
Permalink: http://link.aip.org/link/?APPLAB/83/575/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.63.Lk
    Visible radiation: diaphanography, transillumination, laser imaging in medicine
  • 85.35.Be
    Quantum well devices including quantum dots, quantum wires, etc
  • 42.40.My
    Applications of holography
  • 87.19.Xx
    Diseases
  • YEAR: 2003

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PUBLICATION DATA

ISSN:
0003-6951 (print)   1077-3118 (online)
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REFERENCES (15)
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