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Single-metalloprotein wet biotransistor

Appl. Phys. Lett. 86, 133902 (2005); doi:10.1063/1.1896087

Published 23 March 2005

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Andrea Alessandrini and Marco Salerno
INFM National Research Center on "nanoStructures and bioSystems at Surfaces" (S3), I-41100, Modena, Italy

Stefano Frabboni
Department of Physics, University of Modena and Reggio Emilia, I-41100, Modena, Italy and INFM National Research Center on "nanoStructures and bioSystems at Surfaces" (S3), I-41100, Modena, Italy

Paolo Facci
INFM National Research Center on "nanoStructures and bioSystems at Surfaces" (S3), I-41100, Modena, Italy
Metalloproteins are redox molecules naturally shuttling electrons with high efficiency between molecular partners. As such, they are candidates of choice for bioelectronics. In this work, we have used bacterial metalloprotein azurin, hosted in a nanometer gap between two electrically biased gold electrodes, to demonstrate an electrochemically gated single-molecule transistor operating in an aqueous environment. Gold-chemisorbed azurin shows peaks in tunneling current upon changing electrode potential and a related variation in tunneling barrier transparency which can be exploited to switch an electron current through it. These results suggest the wet approach to molecular electronics as a viable method for exploiting electron transfer of highly specialized biomolecules. ©2005 American Institute of Physics
History: Received 29 November 2004; accepted 15 February 2005; published 23 March 2005
Permalink: http://link.aip.org/link/?APPLAB/86/133902/1
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