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Photoacoustic imaging of early inflammatory response using gold nanorods

Appl. Phys. Lett. 90, 223901 (2007); doi:10.1063/1.2743752

Published 29 May 2007

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Kang Kim, Sheng-Wen Huang, Shai Ashkenazi, and Matthew O'Donnell
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109

Ashish Agarwal and Nicholas A. Kotov
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109

Michael F. Denny and Mariana J. Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109
Gold nanorods have unusually strong absorption in near infrared, which can be utilized for an optical imaging with nanocolloids. The feasibility of photoacoustic imaging of inflammatory responses using bioconjugated gold nanorods is demonstrated. To target the stimulated cells, gold nanorods were conjugated to anti-intercellular adhesion molecule-1 (ICAM-1) which binds to cell surfaces over expressing ICAM-1. A monolayer of stimulated endothelial cells labeled with bioconjugated gold nanorods was scanned using a high frequency transducer. Photoacoustic images differentiated inflamed cells from control cells and matched well with fluorescence images. This technology may permit identification of critical inflammation sites such as blood vessels. ©2007 American Institute of Physics
History: Received 6 March 2007; accepted 1 May 2007; published 29 May 2007
Permalink: http://link.aip.org/link/?APPLAB/90/223901/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.63.Df
    Ultrasonography (medical imaging)
  • 43.80.Qf
    Medical diagnosis with acoustics
  • 43.80.Vj
    Acoustical medical instrumentation and measurement techniques
  • 87.83.+a
    Biomedical applications of nanotechnology
  • 87.63.Lk
    Visible radiation: diaphanography, transillumination, laser imaging in medicine
  • 43.35.Ud
    Thermoacoustics, high temperature acoustics, photoacoustic effect
  • 87.16.-b
    Subcellular structure and processes
  • 87.19.Uv
    Haemodynamics, pneumodynamics
  • YEAR: 2007

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PUBLICATION DATA

ISSN:
0003-6951 (print)   1077-3118 (online)
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