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Nanopore in metal-dielectric sandwich for DNA position control

Appl. Phys. Lett. 91, 153103 (2007); doi:10.1063/1.2798247

Published 8 October 2007

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Stas Polonsky, Steve Rossnagel, and Gustavo Stolovitzky
IBM T. J. Watson Research Center, P.O. Box 218, Yorktown Heights, New York 10598, USA
We present the concept of a nanoelectromechanical device capable of controlling the position of DNA inside a nanopore with a single nucleotide accuracy. The device utilizes the interaction of discrete charges along the backbone of a DNA molecule with the electric field inside the nanopore. In analogy to solid state transistors in which a small voltage controls the current between two electrodes, a voltage strategically located inside the nanopore can control the translocation of a single DNA molecule between a cis and a trans reservoirs. We propose an immediate application of the device as a replacement of capillary electrophoresis in DNA sequencing. ©2007 American Institute of Physics
History: Received 24 July 2007; accepted 23 September 2007; published 8 October 2007
Permalink: http://link.aip.org/link/?APPLAB/91/153103/1
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KEYWORDS and PACS

Keywords
PACS
  • 82.37.Rs
    Single molecule manipulation of proteins and other biological molecules (chemical kinetics)
  • 85.85.+j
    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
  • 82.39.Pj
    Nucleic acids, DNA and RNA bases (chemical kinetics)
  • YEAR: 2007

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PUBLICATION DATA

ISSN:
0003-6951 (print)   1077-3118 (online)
Publisher:
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REFERENCES (6)
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